肺表面活性物质治疗豚鼠哮喘模型的病理学研究

Pathological study on therapy of pulmonary surfactant in the asthmatic model of guinea pigs

摘要:

目的 观察肺表面活性物质(PS)气管内滴入治疗哮喘后气道病理形态学变化。方法 用卵蛋白致敏法建立豚鼠哮喘模型，并分析哮喘发作及PS治疗30分钟后细支气管病理改变。结果 哮喘组细支气管平滑肌痉挛，管腔内较多炎性渗出物，管壁内大量炎症细胞浸润；PS治疗组平滑肌痉挛缓解，管腔内渗出物消失，管壁炎症细胞浸润减少。结论 外源性PS可缓解平滑肌痉挛，并有减轻气道炎症反应的客观征象。

Abstract:

Objective To observe the pathological changes in asthma after being treated with pulmonary surfactant (PS) dripped into the airway. Methods The asthmatic model was set up using guinea pigs immunized against ovalbumin. The pathological changes of bronchioles from five asthmatic animals and five treated ones were compared thirty minutes after the dripping of 0.3 ml PS into the airway. Results There were marked smooth muscle spasm, inflammatory cell infiltration and a large amount of exudate in the airway lumen in the asthma group. After being treated with PS, the inflammatory exudate disappeared and cell infiltration was alleviated. Conclusions Exterior PS could relieve spasm of bronchiole smooth muscle and alleviate airway inflammation.