小儿病毒性心肌炎与柯萨奇B组病毒抗体的关系探讨

Relationship Between Viral Myocarditis in Children and Antibodies Against Coxsackie B Viruses

摘要:

目的 探讨柯萨奇B组病毒抗体IgM测定在心肌炎病原学诊断和临床诊断中的意义。方法 1996～1998年儿科住院病人70例，分为心肌炎组20例，疑似心肌炎组25例，对照组25例。用间接酶联免疫吸附法(ELISA)测定柯萨奇B组病毒抗体IgM和IgG。 结果柯萨奇B组病毒抗体IgM阳性心肌炎组11例(55%)，疑似心肌炎组11例(44%)，对照组11例(44%)，经统计学处理，其差别无显著性意义。结论 用ELISA法测定柯萨奇B组病毒抗体IgM，阳性提示有柯萨奇B组病毒感染，对心肌炎患儿可以作出病因和病原学诊断，但不能以此作为临床诊断心肌炎的依据。

Abstract:

Objective To study the detection of IgM antibodies against coxsackie B viruses and their significance of etiology and diagnosis for patients with myocarditis. Method seventy pediatric patients were divided into three groups: 20 cases of myocarditis, 25 cases of suspect myocarditis and 25 cases of the control group. The presence of CBV - IgM and CBV - IgG was detected by indirect ELISA. Results The test revealed 11 of 20 (55% ) CBV - IgM opitives in the myocarditis group, 11 of 25 (44% ) CBV- IgM positives in the indirect myocarditis group and 11 of 25 (44% ) CBVIgM positives in the control group. There were no significant differences among the three groups (x2 = 1. 1286, P > 0. 05). Conclusions The presence of CBV-IgM positive by indirect ELISA indicates that the patient is infected by CBV. It Is an etiologic evidence of patients with myocarditis. But it is not a clinical diagnostic evidence of patients with myocarditis.