载脂蛋白E基因多态性对儿童血脂的影响

Influence of Apolipoprotein E Polymorphism on Serum Lipids in Children

摘要:

目的： 研究载脂蛋白E(APOE)基因多态性是否影响了中国学龄儿童的血脂水平。方法： 检测214名本地的两所小学四年级和五年级儿童的血脂,其中男116名,女98名,年龄8～12岁。用多聚酶链反应检测APOE基因型。结果： APOE的基因型分布为E3/ 3148例 (6 9.2 %) ,E4/ 34 1例 (19.1% ) ,E2 / 32 0例 (9.3% ) ,E4/ 45例 (2 .4% ) ,E 2/4和E2/ 2未检测到;血清总胆固醇和低密度脂蛋白胆固醇及载脂蛋白B按E4>E3>E2的顺序减低,且有统计学意义(P<0.05),高密度脂蛋白胆固醇和载脂蛋白A1,甘油三酯则按上述顺序升高,但均无统计学意义 (P>0.05)。结论： APOE基因多态性对血脂的影响在中国汉族学龄儿童中存在。

Abstract:

OBJECTIVE: To determine whether APOE influences the serum levels of lipid and lipoprotein. METHODS: The distribution of apolipoprotein E phenotypes was investigated in 214 children of 2 primary schools (aged 8～12, 116 males and 98 females). Phenotypes of APOE were examined with PCR. RESULTS: The E 3/3 phenotype was demonstrated in 69.2% , E 4/3 in 19.1% , E 2/3 in 9.3% and E 4/4 in 2.4% , and E 2/2 and E 2/4 were not detected. The serum levels of total cholesterol and low density lipoprotein cholesterol and apolipoprotein B were progressively lower in phenotypes E4, E3 and E2. The serum levels of HDL C, APOA1 and TG showed no statistic difference.CONCLUSIONS: APOE phenotypes do influence serum lipids of Chinese school children.