单纯性肾病患儿甲状腺功能测定的临床意义

Determination of the Thyroid Function for Simple Nephropathy Children

摘要:

目的： 探讨单纯性肾病血清甲状腺素水平的变化。方法： 用双抗体放免法检测肾病患儿组与健康对照组各 20例血清甲状腺素,比较两组变化的差异。结果： 对照组血清甲状腺素水平正常,肾病组血清T3 ,T4 ,TSH有不同程度的变化 ,分别为 (1.0± 0 .5)nmol/L ,(15.5±32.4)nmol/L,(20.2±13.2)mU/L,两组差异有显著性意义(P<0.01)。结论： 检测单纯性肾病患儿血清甲状腺素水平,对增进治疗效果,估计和改善预后有比较重要的意义。

Abstract:

OBJECTIVE: To investigate the changes of serum thyroid hormone levels in children with the simple nephrotic syndrome.METHODS: We measured the serum thyroid hormone levels in a group of simple nephrotic syndrome children (n=20) and a group of healthy controls (n=20) by radioimmunoassay double antibody (RIA-DA), and then compared the differences in serum thyroid hormone levels the 2 groups by a statistical method. RESULTS: The thyroid hormone levels in the contorl group were normal, but the serum T 3, T 4, TSH in the nephrotic syndrome group showed changes of different degrees. They were (1.0 ±0.5) nmol/L, (15.5 ± 32.4) nmol/L, and (20.2±13.2 ) mU/L, respectively. There was a significant difference between the simple nephrotic syndrome group and the controls (P< 0.01). CONCLUSIONS: There might be some significance in using serum thyroid hormone levels in children with the simple nephrotic syndrome for the improvement of management, curative effect and evaluation of prognosis.