多烯康治疗儿童激素敏感型肾病综合征高脂血症疗效观察

Reatment of the Steroid Sensitive Nephrotic Syndrome Complicated by Hyperlipoidemia in Children

摘要:

目的：观察糖皮质激素治疗后(10周内)多烯康治疗儿童激素敏感型肾病综合征(SSNS)高脂血症的疗效。方法：SSNS患儿随机分为降脂治疗组(治疗组)和对照治疗组(对照组)，均给予糖皮质激素标准疗程，治疗组加用多烯康。分别在治疗前，治疗后2～3周，5～6周，8～10周采空腹血观察4种血脂成分：总胆固醇(TC)，三酰甘油(TG)，高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)。结果：疗程2～3周治疗组LDL-C(3.19±2.08) mmol，TC(6.42±2.04) mmol均显著低于对照组(5.82±2.73) mmol/L，(10.0±4.75) mmol/L，(P均<0.05)。第5～6周治疗组LDL-C(2.83±1.50) mmol较对照组(4.94±2.04) mmol/L，提前下降至低水平(P<0.01)，第8～10周治疗组LDL-C(2.30±0.46) mmol/L仍明显低于对照组（4.20±2.22）mmol/L，(P<0.01)。结论：多烯康能显著缩短SSNS严重高脂血症的时间，尤其是对降(LDL-C)有显著疗效，减轻了高脂血症对肾脏继发性损害的饿威胁。

Abstract:

OBJECTIVE: To investigate the therapeutic effect of Duoxikang capsula (DXK) on hyperlipoidemia in children with the steroid sensitive nephrotic syndrome (SSNS). METHODS: Twenty SSNS children were randomly divided into a DXK treated group and a control group. DXK was then administered (45 mg/kg weight daily) in the DXK treated group and the same regular steroid therapeutic measurements were conducted in two groups of SSNS. Bloodlipoid compliments were determined, including total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoproteincholesterol (LDL-C) before the randomization, and again 2～3 weeks, 5～6 weeks, 8～10 weeks after the treatment. RESULTS: During the 2～3 weeks, levels of LDL-C ［(3.19±2.08) mmol and TC ［(6.42±2.04) mmol］ in the DXKtreated group were markedly lower than those in the control group ［(5.82±2.73) mmol, (10.0±4.75) mmol, respectively］ (both P<0.05). During the 5～6 weeks and 8～10 weeks, the level of LDL-C in the DXK treated group was also lower than that in the control group ［(2.83±1.50) mmol vs (4.94±2.04) mmol; (2.30±0.46) mmol vs (4.20±2.22) mmol, respectively. P<0.01 . CONCLUSIONS: DXK treatment reduced severe hyperlipoidemia, especially LDL-C in children with SSNS. It is suggested that DXK treatment may reduce the secondary renal injury in these children.