Lung Function Test via Tidal Breathing in Infants before and after the Treatment of Pneumonia

摘要:

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Abstract:

OBJECTIVE: To study the lung function changes of infants with pneumonia via tidal breathing pattern analysis before and after treatment. METHODS: Tidal Flow Volume Loops(TFV) were measured using the tidal breathing pattern in 58 infants (1～40 months old) with pneumonia. Sixty three normal infants were used as controls. The parameters, including respiratory rate (RR), inspiratory and expiratory time (Ti, Te), the ratio of Ti/Te, peak tidal expiratory flow (PTEF), the ratio of time to reach peak tidal expiratory flow (TPTEF)to total expiratory time (TE), the ratio of volume to reach peak tidal expiratory flow (VPEF) to total expiratory volume (VE), tidal volume per kilogram (VT/kg), mean inspiratory flow (MIF), mean expiratory flow (MEF), and tidal expiratory flow at 25%, 50%,75% lung volume(TEF 25%, TEF 50% and TEF 75%) were measured using the MasterscreenPaediatric (a tool for the lung function test). RESULTS: RR increased, TPTEF, TPTEF/TE, VPEF, VPEF/VE were lower in infants with pneumonia compared with those ofthe controls ［RR= (36±9)/min vs (30±8)/ min, TPTEF= (0.20±0.08) s vs (0.40±0.16) s, TPTEF/TE=(18.8±5.8)% vs (33.0±7.5)%, VPEF=(17.2±10.9) ml vs (25.4±12.8) ml, VPEF/VE=(22.1±4.6)% vs (33.4±6.35)%］(P<0.01). TI,TE, TI/TE were shortened. It appeared that the airway was obstructive. After the routine therapy, RR decreased to (33±11)/min, TPTEF/TE and VPEF/TE were significantly higher ［(26.2±8.7) and (8.4±7.3)% , respectively］(P<0.01). CONCLUSIONS: Tidal breathing pattern can be used to evaluate the lung function and the effect of therapy in infants with pneumonia.