糖皮质激素对肾病患儿血清中细胞因子的影响

Effect of Glucocorticoid on Serum Cytokines in Children with the Nephrotic Syndrome

摘要:

目的：探讨糖皮质激素对肾病综合征(NS)患儿血清中白细胞介素1(IL-1)，白细胞介素 6(IL-6)，白细胞介素8(IL-8)和肿瘤坏死因子α(TNFα)的影响。方法：将24例NS患儿分为激素治疗前和治疗后两组，应用间接酶联免疫吸附试验(ELISA)检测血清中IL-1，IL-6，IL-8和TNFα的水平。结果：NS患儿激素治疗前后血清中IL-1［(195±25) ng/L vs (120±25) ng/L］，IL-6［(355±62) ng/L vs (200±23) ng/L］，IL-8［(286±55) ng/L vs (178±32) ng/L］和TNFα［(265±36) ng/L vs (110±40) ng/L］水平差异有显著性意义(P<0.01)。结论：糖皮质激素可能对NS患儿血清中多种细胞因子有抑制作用。

Abstract:

OBJECTIVE: To explore the effect of glucocorticoid on serum IL-1, IL-6, IL-8 and TNFα in children with the nephrotic syndrome (NS). METHODS: IL-1, IL-6, IL-8 and TNFα in serum were detected using ELISA in 24 children with NS before and after the treatment with glucocorticoids. RESULTS: Significant differences of IL-1 ［(195±25) ng/L vs (120±25) ng/L］, IL-6 ［(355±62) ng/L vs (200±23) ng/L］, IL-8 ［(286±55) ng/L vs (178±32) ng/L］ and TNFα ［(265±36) ng/L vs (110±40) ng/L］ were found between the two groups before and after the treatment (P<0.01). CONCLUSIONS: It is suggested that glucocorticoids might inhibit serum IL-1, IL-6, IL-8 and TNFα in children with NS.