哮喘儿童呼出气一氧化氮水平的测定

Level of Exhaled Nitric Oxide in Asthmatic Children

摘要:

目的： 探讨哮喘儿童呼出气一氧化氮(exhalednitricoxide,eNO)水平及其意义。方法： 设定13～15cmH2O呼出气阻力以关闭软腭,用化学发光法测定34例6～14岁哮喘儿童和36名6～13岁非呼吸道疾病儿童单次呼吸的eNO浓度 ,同时测定一秒钟用力呼气容积占预计值百分比 (FEV1%)。结果：哮喘儿童的eNO浓度为 (89.4± 56 .4) ppb ,较非呼吸道疾病儿童eNO浓度 [(15 .8±5.8) ppb]显著增高 (P<0.01) ;哮喘儿童eNO浓度与FEV1%之间无显著相关性(r=0.06 ,P>0.05)。结论： 哮喘儿童eNO浓度高于正常,其变化与FEV1%无关。

Abstract:

OBJECTIVE: To investigate the level of exhaled nitric oxide (NO) in children with asthma. METHODS: In 34 asthmatic children (aged 6～14 years) and 36 non respiratory disease subjects, exhaled NO with 13～15 cmH 2O expiratory airway pressure was measured by the chemiluminescent NO analyzer of the online method and the FEV 1 % was measured by a pocket spirometer at the same time. RESULTS: The level of exhaled NO of asthmatic children was significantly higher than that of the non respiratory disease subjects [( 89.4 ± 56.4 ) ppb vs ( 15.8 ± 5.8 ) ppb](P< 0.01 ). There was no significant correlation between exhaled NO and FEV 1% in asthmatic children (r= 0.06 ,P> 0.05 ). CONCLUSIONS: The level of exhaled NO in asthmatic children is higher than that of normal subjects.