肌钙蛋白Ⅰ在新生儿胎粪吸入综合征并心肌损伤诊断中的意义

Cardiac Troponin Ⅰ in the Diagnosis of the Meconium Aspiration Syndrome with Myocardial Lesions in Neonates

摘要:

目的 探讨心肌肌钙蛋白Ⅰ(CTn-Ⅰ)在新生儿胎粪吸入综合征(MAS)并心肌损伤诊断中的意义。方法：用化学发光免疫法及酶法分别测定35例合并心肌损伤的MAS患儿、30例无心肌损伤的MAS患儿及15例正常对照组血清CTn-Ⅰ及CK-MB的水平。结果：心肌损伤组生后2～3 d CTn-Ⅰ浓度为(0.67±0.13) ng/ml，较MAS对照组［(0.07±0.05) ng/ml］和正常对照组［(0.07±0.03) ng/ml］明显升高，差异有显著性意义(P<0.05)。结论：CTn-Ⅰ是诊断新生儿MAS并心肌损伤的特异性指标之一。

Abstract:

OBJECTIVE: To evaluate the diagnostic value of serum cardiac troponin Ⅰ (CTn Ⅰ) in the neonatal meconium aspiration syndrome (MAS) with myocardial lesions. METHODS: Serum CTn Ⅰ and CK MB levels were determined by the chemiluminoimmunoassay and enzyme assay in 65 neonates of MAS with or without myocardial lesions (n=35 and n=30, respectively) and 15 normal newborns. RESULTS: The serum CTn Ⅰ level in the neonates of MAS with myocardial lesions [( 0.67 ± 0.13 ) ng/ml] was much higher than that in those without myocardial lesions [( 0.07 ± 0.05 ) ng/ml] and normal neonates [( 0.07 ± 0.03 ) ng/ml] on day 2～3 of life (P< 0.05 ). CONCLUSIONS: CTn Ⅰ appears to be one of the specific markers for the diagnosis of MAS with myocardial lesions in neonates.