中枢神经系统疾病合并全身炎症反应综合征患儿血清TNF-αIL-1βIL-6的动态变化及意义

Dynamic Changes of Serum TNF-α，IL-1β and IL-6 in Children with Central Nervous System Diseases and the Systemic Inflammatory Response Syndrome

摘要:

目的：探讨细胞因子在中枢神经系统疾病合并全身炎症反应综合征(SIRS)及多器官功能障碍综合征(MODS)发生发展中的意义及其与SIRS/MODS严重程度的相关性，以初步探讨SIRS及MODS的发生机制，为临床防治提供理论依据。方法：选择该院PICU神经系统疾病患儿26例，用IMMULITE化学发光免疫分析仪测定入院第1，3，5天TNF-α，IL-1β，IL-6的含量。结果：第1，3，5天TNF-α，IL-1β，IL-6含量在SIRS组、MODS组及死亡组均较非SIRS组、非MODS组及非死亡组明显升高(P<0.05)。且死亡组上述各项指标均持续维持在较高水平。结论：TNF-α，IL-1β，IL-6的含量可反映病情严重程度，为探讨细胞因子在SIRS/MODS发病机制中的作用提供了依据，指导临床早期诊断、治疗。

Abstract:

OBJECTIVE:To study the dynamic changes and the role of serum cytokines in the systemic inflammatory response syndrome (SIRS)/and multiple organ dysfunction syndrome(MODS) caused by central nervous system (CNS) diseases and the relationships with the severity of SIRS/MODS. METHODS: Twenty six children with CNS diseases admitted to the PICU were assigned into the SIRS group (n=16) and non SIRS group (n=11). The levels of TNF α,IL 1β and IL 6 were determined using the immulite chemiluminescent immunometric analyzer for the two groups on day 1, 3 and 5. RESULTS: The levels TNF α,IL 1β and IL 6 in the SIRS group were remarkably higher than those in the non SIRS group on day 1, 3 and 5 (P< 0.05 ). In the SIRS group, the levels of TNF α,IL 1β and IL 6 in the MODS cases and death cases were significantly higher than those in the non MODS cases and non death cases on day 1, 3 and 5 (P< 0.01 ). Moreover, these indexes of the death patients remained high continuously. CONCLUSIONS:TNF α, IL 1β and IL 6 may be valuable in assessing the degree of severity and the prognosis of SIRS/MODS caused by CNS diseases. They are helpful in making effective treatments and preventive measures for SIRS/MODS caused by CNS diseases.