缺氧缺血性脑病新生儿血浆神经肽Y和降钙素基因相关肽的变化

Changes of Serum Neuro Peptide Y and Calcitonin Gene Related Peptide in Neonates with Hypoxic Ischemic Encephalopathy

摘要:

目的：研究缺氧缺血性脑病新生儿血浆神经肽Y(NPY)和降钙素基因相关肽(CGRR)的变化。方法：采用放免法动态观察42例中度HIE患儿和30例正常对照组NPY和CGRP在急性期和恢复期的变化以及与脑血流的相关性。结果：观察组NPY总体水平高于对照组,尤以窒息后第2,3天为著[(168.3±10.9)ng/L vs(86.7±5.4)ng/L],差异有显著性(P<0.01);观察组CGRP总体水平低于对照组,尤以窒息后第2,3天为著[(48.4±3.7)ng/L vs(81.3±16.8)ng/L],差异有显著性(P<0.01)。结论：NPY,CGRP在HIE的发病机理中可能起重要的作用,参与了HIE的发生和发展;HIE第2～3天脑血管痉挛收缩,是应用扩血管治疗的最佳时期。

Abstract:

OBJECTIVE: To study the dynamic changes of serum neuro peptide Y (NPY) and calcitonin-gene related peptide (CGRP) in neonates with hypoxic-ischemic encephalopathy (HIE). METHODS: Forty-two neonates with HIE (Group A) and 30 normal neonates (controls, Gruop B) were enrolled in this research. Their serum contents of NPY and CGRP were measured with the radio-immuno-assay, and the cranial blood flow was recorded at the same time. RESULTS: The serum NPY content in Group A was significantly higher than that in Group B, especially on day 2 to day 3 following asphyxia [(168.3±10.9) ng/L vs (86.7±5.4) ng/L]( P <0.01). The serum CGRP content in Group A was lower than that in Group B, especially on day 2 to day 3 after asphyxia [(48.4± 3.7) ng/L vs (81.3±6.8) ng/L] ( P <0.01). CONCLUSIONS: NPY and CGRP might be important factors in the development of HIE. The dynamic measures of NPY and CGRP contents might be useful in determining the clinical management of HE. [Chin J Comtemp Pediatr, 2003, 5(1): 27 - 28]