新生儿血清瘦素水平与生长发育关系研究

Relationship Between the Serum Leptin Level and Growth & Development in Newborns

摘要:

目的：探讨新生儿血清瘦素与生长发育的关系。方法：采用放射免疫法检测80例新生儿静脉血和脐血瘦素水平,其中66例足月儿分为大于胎龄儿(LGA)组18例,适于胎龄儿(AGA)组32例,小于胎龄儿(SGA)组16例。采用Rohrer’s指数=出生体重(g)×100/身长(cm)~3估测新生儿营养状态。结果：早产儿血清瘦素水平明显低于足月儿[(0.66±1.03)ng/ml vs(3.59±2.16)ng/ml],P<0.01;足月儿中AGA血清瘦素水平[(3.06±0.96)ng/ml]明显低于LGA[(4.03±2.22)ng/ml],而高于SGA[(1.13±1.98)ng/ml];足月新生儿血清瘦素水平与Rohrer’s指数、新生儿体重、胎龄呈显著正相关(r=0.61,0.68,0.62,P均<0.01)。结论：新生儿体内瘦素是反映新生儿的发育和营养状态的有用指标。[中国当代儿科杂志,2003,5(1):29-30]

Abstract:

OBJECTIVE: To study the relationship between the serum leptin level and growth & development in newborns. METHODS: The serum leptin level was examined by the radioimmunoassay (RIA) in 14 premature neonates and 66 term neonates. The term newborns were assigned into the large for gestational age (LAG) group (n= 18), the appropriate for gestational age (AGA) group (n = 32) and the small for gestational age (SGA) group (n = 16). The neonatal nutritional status was evaluated by Rohrer' s index. RESULTS: The leptin level in the preterm newborns was significantly lower than that in the term neonates [ ( 0. 66 ±1. 03) ng/ml vs (3. 59 ± 2.16 ) ng/ml ] ( P < 0.01). The leptin level in the AGA newborns [(3.06 ±0.96) ng/ml] was significantly lower than that in the LGA neonates [(4. 03 ±2.22) ng/ml], and was significantly higher than that in the SGA neonates [(1.13 ±1.98) ng/ml]. The serum leptin level was positively correlated with Rohrer' s index, neonatal weight and gestational age in the term neonates ( r =0.61, 0.68, 0.62, respectively; all P <0.01). CONCLUSIONS: The serum leptin level may be a valuable index to evaluate neonatal growth and nutrional status. [Chin J Contemp Pediatr, 2003, 5(1): 29-30]