吸入一氧化氮对持续肺高压新生儿血小板聚集功能的影响

Effect of Nitric Oxide Inhalation on Platelet Aggregation in Neonates with Persistent Pulmonary Hypertension

摘要:

目的：探讨一氧化氮(NO)吸入治疗新生儿肺高压(PPHN)过程中血小板聚集功能的变化。方法：采用比浊法测定PPHN患儿吸入NO 6h后血小板在肾上腺素、胶原和二磷酸腺苷(ADP)诱导下的聚集率。结果：3种诱导剂引起血小板聚集的作用均明显受到抑制,与对照组相比分别为(0.39±0.11)％vs(0.48±0.10)％;(0.41±0.19)％vs(0.69±0.22)％;(0.32±0.12)％vs(0.50±0.16)％,差异均有显著性(P<0.05或0.01)。结论：PPHN患儿吸入NO后,血小板聚集能力明显受到抑制,存在加重临床出血的可能性。

Abstract:

OBJECTIVE: To study the effect of nitric oxide (NO) inhalation on platelet aggregation in neonates with persistent pulmonary hypertension. METHODS: The platelet aggregartion rate with the induction of epinephrine, collagen and adenosine diphosphate (ADP) was assayed by turbidimetry 6 hours after NO inhalation in 11 neonates with persistent pulmonary hypertension (NO inhalation group). Twelve neonates with this disorder receiving oxgen inhalation served as the controls. RESULTS: The platelet aggregation rate with the induction of epinephrine, collagen and ADP was significantly inhibited in the NO inhalation group compared with the controls: (0.39 ±0.11)% vs (0.48±0.10)%, (0.41±0.19)% vs (0.69 ± 0.22)%, (0.32±0.12)% vs (0.50 ± 0.16)%, respectively ( P <0.05 or 0.01). CONCLUSIONS: NO inhalation may restrain platelet aggregation and increase hemorrhage risk.