川崎病患儿抗心磷脂抗体检测的意义

Detection of Anticardiolipin Antibodies in Children with Kawasaki Disease

摘要:

目的：检测川崎病(KD)患儿血清中抗心磷脂抗体(ACA),探讨ACA与KD血管损害的关系。方法：55例急性期KD患儿,采用ELISA方法检测血中ACA-IgG,IgM和IgA三种亚型。结果：55例急性期KD患儿血清ACA-IgG阳性31例,ACA-IgM阳性13例。急性期KD组ACA-IgG,IgM阳性率比对照组显著增高(P<0.01);治疗后ACA-IgG阳性率仍高于对照组(P<0.05),而ACA-IgG阳性或阴性两组的临床表现比较差异均无显著性(P>0.05),但6例伴有血栓形成者有5例ACA-IgG阳性。结论：ACA-IgG是KD常见的抗体,ACA-IgG阳性与KD血栓性血管损害关系密切,但对病情判断无作用。

Abstract:

OBJECTIVE: To study the relationship between anticardiolipin antibodies (ACA) and vascular injury in children with Kawasaki disease (KD). METHODS: Serum ACA-IgG, IgM and IgA were measured qualitatively using ELISA in 55 children with KD. Thirty healthy children served as the controls. RESULTS: In the children with KD, serum ACA-IgG and IgM were found to be positive in 56.4% (31/55) and 23.6% (13/55), respectively. No ACA antibodies were found in the controls ( P <0.01). Severity of clinical manifestations in the children with KD positive or negative for ACA-IgG did not differ. Of the 6 children with KD complicated by coronary thrombus, there were 5 cases of positive ACA-IgG. CONCLUSIONS: ACA-IgG, the most common antibody in children with KD, is correlated to vascular injury, but is not useful in evaluating the severity of KD.