声学密度技术定量评价缺氧肺动脉高压对左室心肌损伤的实验研究(英文)

Experimental Study of Acoustic Densitometry in Detecting Left Ventricular Myocardium Damage Secondary to Hypoxic Pulmonary Hypertension

摘要:

目的：探讨声学密度定量(AD)技术定量评价缺氧肺动脉高压(PH)后左室心肌损害的应用价值。方法：在建立缺氧肺动脉高压兔模型的基础上，应用AD技术对PH组和正常对照组兔左室相应部位心肌密度值进行测定。结果：与正常组比较，缺氧PH组左室前壁的背向散射强度标准差(SDI)及背向散射强度周期性变化幅度(CVIB)差异无统计学意义(P>0.05)，但心动周期背向散射强度平均值(AII)明显升高(P<0.05)；室间隔中部CVIB明显减低(P<0.05)，AII明显升高(P<0.05)；左室后壁AII明显升高(P<0.05)。PH组左室心肌不同部位AII值与左室舒张未压(LVDEP)成正相关(r=0.6206～0.6311，P<0.01)。结论：AD技术对判定缺氧PH后左室心肌损伤改变较为客观、简便，有较高的应用价值。

Abstract:

OBJECTIVE: To evaluate the value of acoustic densitometry (AD) in detecting myocardium damage of the left ventricle secondry to hypoxic pulmonary hypertension (PH). METHODS: Using the rabbit model of hypoxic PH, the density of various locations of the left ventricular myocardium in the hypoxic PH group and the normal control group were detected by the technique of AD. RESULTS: Compared with the normal control group, average image intensity (All) of the left ventricular anterior wall (LVA) in the hypoxic PH group increased ( P <0.05), while the difference between the standard deviation intensity (SDI) and peak to peak intensity (CVIB) of LVA were not significantly different ( P > 0.05). The CVIB of the middle of the interventricular septum (IVSM) in the hypoxic PH group was lower than that of the normal control group ( P <0.05). The All of IVSM and the left ventricle posterior wall (LVPW) in the hypoxic PH group were higher than those of the normal control group ( P < 0.05). In various locations of the left ventricular myocardium, the value of All and the left ventricle diastolic end pressure (LVDEP) were positively related ( r = 0.6206 -0.6311, P <0.01). CONCLUSIONS: The AD technique is useful in evaluating the extent of damage of the left ventricular myocardium in hypoxic PH.