新生儿窒息母儿血浆催乳素水平变化的研究(英文)

Changes of Maternal and Neonatal Plasma Prolactin Levels in Neonatal Asphyxia

摘要:

目的：目前发现催乳素(PRL)与缺氧缺血性脑病(HIE)的严重程度密切相关，PRL与新生儿窒息的关系较少报道，该文探讨窒息新生儿母儿血浆催乳素(PRL)水平变化与相关性及其意义。方法：采用放射免疫分析法对25例围产期窒息新生儿(窒息组，其中轻度窒息14例，重度窒息11例)及20例正 Ｐ律?对照组)母血、脐血及新生儿血浆PRL水平进行测定并进行动态观察。结果：窒息组母血、脐血及新生儿血浆PRL水平［(362.5±127.1)，(984.6±262.3)，(386.3±216.2)μg/L］均显著高于对照组［(96.4±26.2), (92.3±18.4), (68.7±7.27)μg/L］(P均<0.01)；重度窒息组母血、脐血及新生儿血浆PRL水平［(445±216)，(996±284)，(412±221) μg/L］均高于轻度窒息组［(298±102), (612±221), (309±19.2) μg/L］(P<0.01或0.05)。轻、重度窒息组中脐血与新生儿血浆PRL水平具有显著的正相关关系(r=0.54，0.63，P<0.05)。窒息新生儿复苏后血浆PRL水平高于对照组(P<0.01)；生后第2天PRL水平逐渐下降，但仍高于对照组(P<0.05)；生后第10天血浆PRL水平与对照组差异无显著性(P>0.05)。结论：围产期窒息时新生儿血浆、脐血及母血PRL水平显著增高，血浆PRL水平可作为判断新生儿窒息程度的一项参考指标。

Abstract:

OBJECTIVE: Some research has shown that prolactin (PRL) is closely related to severity of hypoxic ischemic encephalopathy (HIE). However, the role of maternal and neonatal plasma PRL levels in neonatal asphyxia has not been reported so far. This paper aims at studying the changes of PRL levels in the cord blood, maternal blood and plasma of newborns in neonatal asphyxia. METHODS: The maternal blood, cord blood and neonatal plasma PRL levels in 25 neonates with asphyxia (asphyxia group) and 20 normal ones (control group) were detected by radioimmunoassay. RESULTS: The maternal blood, cord blood and neonatal plasma PRL levels [( 362.5 ± 127.1 ), ( 984.6 ± 262.3 ) and ( 386.3 ± 216.2 ) μg/L, respectively] in the asphyxia group were significantly higher than those in the control group [( 96.4 ± 26.2 ), ( 92.3 ± 18.4 ) and ( 68.7 ± 7.27 ) μg/L, respectively] (P< 0.01 ). The maternal blood, cord blood and neonatal plasma PRL levels [(445±216), (996±284) and (412±221) μg/L, respectively] in the severe asphyxia group were higher than those in the mild asphyxia group [(298±102), (612±221) and (309± 19.2 ) μg/L, respectively] (P< 0.01 or 0.05 ). The cord blood and neonatal plasma PRL levels had a positive correlation both in the mild and the severe asphyxia group (r= 0.54 , r=0.63, both P< 0.05 ). The plasma PRL level right after resuscitation was higher than that of the control group (P< 0.01 ). It gradually reduced from the 2nd day after birth, but was higher than that of the control group (P< 0.01 ). The PRL level on the 10th day after birth was not different from that of the control group. CONCLUSIONS: The PRL levels of neonatal plasma, cord blood and maternal blood increase in the perinatal asphyxial newborns. The plasma PRL level may be a good marker to evaluate the degree of asphyxia.