新生儿高胆红素血症与胃动素胃泌素水平的相关性研究(英文)

Blood motilin and gastrin levels in term newborns with hyperbilirubinemia

摘要:

目的：新生儿高胆红素血症患儿常出现胃肠道症状。该研究目的是探讨高胆红素血症 (高胆 )对新生儿胃肠激素水平的影响及其可能的发生机制。方法：应用放射免疫分析法 (RIA)对 5 0例高胆患儿空腹状态下血中胃动素、胃泌素浓度进行测定 ,并以 30例正常新生儿作为对照。结果：高胆组患儿血浆胃动素浓度 (6 5 9±37ng/L)明显高于对照组 (4 86± 2 8ng/L) ,差异有显著性意义 (P <0 .0 1) ,且与血清胆红素水平呈正相关 ;血清胃泌素浓度 (12 8± 9ng/L)与对照组 (132± 11ng/L)比较差异无显著性 (P >0 .0 5 )。结论：高胆红素血症新生儿的某些胃肠道症状可能与胃动素分泌异常有关。

Abstract:

OBJECTIVE: Most newborn infants with hyperbilirubinemia have gastrointestinal tract symptoms. The aim of this study is to investigate the effect of hyperbilirubinemia on gastrointestinal hormone levels in newborn infants. METHODS: Fasting plasma motilin and serum gastrin levels were measured using a radioimmunoassay in 50 term newborns with hyperbilirubinemia (Hyperbilirubinemia group). Fasting plasm motilin and serum gastrin levels from thirty normal term newborns were used as controls. RESULTS: The plasma motilin level in the Hyperbilirubinemia group (659±37 ng/L) was significantly higher than that of the controls (486±28 ng/L) (P< 0.01). The plasma motilin level was positively correlated with the serum bilirubin level. The serum gastrin level in the Hyperbilirubinema group was not different from that of the controls. CONCLUSIONS: The plasma motilin level is correlated with the level of bilirubin in the newborn. The abnormal increase in the level of motilin may be related to the development of gastrointestinal symptoms newborns with hyperbilirubinemia.