厌食儿童胃动力改变的探讨

Relationship between anorexia and gastric motility in children

摘要:

目的：探讨小儿厌食症可能的发病机制,观察厌食儿童B超胃排空变化,同时观察口服多潘立酮对其的治疗效果。方法：45例厌食患儿,给予多潘立酮口服每次0.3mg/kg,3次/d,共3周,42例病人于治疗前后进行B超胃排空检查并进行比较分析。另设对照组30例。结果：正常儿童与厌食儿童胃动力学指标有明显差异,厌食儿童治疗前后胃动力学指标亦有明显差异。结论：厌食儿童存在胃电节律紊乱,多潘立酮可明显改善厌食患儿临床症状。

Abstract:

OBJECTIVE: This study examined the changes of the gastric motility and the therapeutic effect of domperidone in children with anorexia. METHODS: Forty-five children with anorexia were given a 3 week-course of oral domperidone, with a dosage of 0.3 mg/kg, three times daily. Before and after treatment the gastric emptying test was performed through the real-time ultrasonography in 42 out of the 45 patients. Thirty healthy children served as controls. RESULTS: There were significant differences in the gastric emptying half-time (GET 1/2), and the frequency and amplitude of antral contractions between the children with anorexia and healthy controls. After domperidone treatment, the GET 1/2 was shortened and the frequency and amplitude of antral contractions were significantly increased in children with anorexia. Their clinical symptoms improved markedly. CONCLUSIONS: The abnormalities of gastric motility might be associated with the development of anorexia. Domperidone was found to be effective in the treatment of childhood anorexia.