呼吸道合胞病毒毛细支气管炎患儿T细胞亚群检测的临床价值

Detection of T cell subgroups in infants with bronchiolitis caused by respiratory syncytial virus

摘要:

目的：呼吸道合胞病毒(RSV)感染所致的毛细支气管炎日后发展为哮喘的机率很高,由于哮喘患儿机体存在明显的免疫功能紊乱,而RSV毛细支气管炎在这方面的研究不多,为此该研究探讨毛细支气管炎患儿T细胞亚群的变化及其临床意义。方法：采用流式细胞术对21例RSV毛细支气管炎患儿及20例正常儿童T细胞亚群进行检测。结果：RSV毛细支气管炎组与对照组外周血T细胞亚群CD4,CD8差异无显著性(P>0.05),CD4/CD8比值RSV毛细支气管炎组高于对照组,差异有显著性(P<0.05)。结论：RSV毛细支气管炎患儿存在与哮喘相似的T细胞亚群变化相关的免疫功能紊乱,提示两者在发病机制上存在一定的联系。

Abstract:

OBJECTIVE: The probability of bronchial asthma following bronchiolitis caused by respiratory syncytial virus (RSV) is high. This paper determined the changes of T cell subgroups in infants with bronchiolitis caused by RSV so as to investigate the association between bronchiolitis caused by RSV and asthma. METHODS: T cell subgroups were detected by flow cytometry in 21 infants with RSV bronchiolitis (Study group, mean age 10 months) and 20 age-matched healthy children (Control group). RESULTS: There were no statistical differences in the levels of CD4 and CD8 between the two groups. However, the ratio of CD4/CD8 in the Study group was significantly higher than that in the Control group (1.56±0.22 vs 1.40±0.28, P<0.05). CONCLUSIONS: The ratio of CD4/CD8 in children with bronchiolitis caused by RSV is elevated. The change of T cell subgroups is similar to that of asthma.