小儿血清脑钠素正常参考范围

Mean values of brain natriuretic peptide in 190 healthy children

摘要:

目的：国外研究显示了血清脑钠素—BNP32和氨基末端脑钠肽(NT-proBNP)水平在小儿心力衰竭诊治中的意义。然而,由于小儿BNP32和NT-proBNP正常范围的缺乏导致其在小儿心脏疾病中的应用受到了限制。该研究测定了正常小儿的BNP32和NT-proBNP水平,为临床应用提供参考。方法：用酶联免疫方法分别测定190名健康小儿血清BNP32和NT-proBNP水平,男95名,女95名,年龄10.60±4.12岁,全部受检者均经体检、心电图等检查证明身体健康。结果：小儿血清BNP32浓度为51.89±48.36pg/mL,第10百分位为27.00pg/mL,第90百分位为75.00pg/mL。血清NT-proBNP浓度为246.04±67.27fmol/mL。两种均无性别间的差异(P>0.05),虽然,女童青春成熟期BNP32和NT-proBNP浓度高于青春前,女童脑钠素高于男童,但均未显示有统计学上的显著差异。结论：该文在国内首次用酶联免疫方法测定中国小儿BNP32和NT-proBNP正常范围,小儿NT-proBNP数据较BNP更为稳定、可靠,为脑钠素水平临床测定提供有价值的参考。

Abstract:

OBJECTIVE: Overseas research has shown the value of brain natriuretic peptide (BNP) in the diagnosis and treatment of heart failure in children. However, a reference range of BNP values is lacking, limiting its clinical application. This study was designed to determine a reference range for children aged 1 to 16 years. METHODS: Plasma BNP (BNP32, NT-proBNP) concentrations were measured in 190 healthy children (95 boys and 95 girls) using an enzyme immunoassay. Their age ranged from 1 to 16 years (mean=10.6±4.2 years). RESULTS: The mean plasma concentration of BNP32 in 190 children was 51.89±48.36 pg/mL, with the 10th and the 90th percentile rank of 27.00 pg/mL and 75.00 pg/mL respectively. The mean plasma concentration of BNP32 in girls was 60.33±62.91 pg/mL, and 44.22± 27.14 pg/mL in boys, but no statistical differences were found. The mean plasma concentration of NT-proBNP in 190 children was 246.04±67.27 fmol/mL. The girls had slightly higher plasma NT-proBNP levels than the boys, but there were no statistical differences between them. Neither plasma BNP32 concentration nor NT-proBNP concentration was related to age. CONCLUSIONS: This study first reported a reference range of BNP values for healthy Chinese children aged 1-16 years. Both age and gender are not related to BNP values.