脑源性神经营养因子与新生儿出生体重的关系

Relationship between brain-derived neurotrophic factor and birth weight in neonates

摘要:

目的：该文通过检测新生儿脐血脑源性神经营养因子（brain-derived neurotrophic factor,BDNF）的水平，探讨BDNF与新生儿出生体重的关系，并对相关因素进行分析。方法：根据出生体重,将51 例足月第1胎健康新生儿分为3 组:①小于胎龄组（SGA）8例；②适于胎龄组（AGA ）31例；③大于胎龄组（LGA）12例。测量新生儿身长、体重及其母亲的身高、体重，并对脐血中BDNF、瘦素（LEP）、胰岛素（INS）、总胆固醇（TC）、甘油三酯（TG）进行检测。结果：SGA组的BDNF明显高于AGA组和大于LGA组，AGA组和LGA组中BDNF没有差异；多元逐步回归分析显示BDNF值与新生儿出生体重、体重指数存在负相关关系。LEP与BDNF不呈相关趋势（P>0.05），INS与BDNF也不呈相关趋势（P>0.05）。INS 与LEP呈现正相关（P<0.05）。LEP与新生儿体重、产妇体重及其BMI呈正相关，而TC，TG在3组新生儿中差异无显著性。结论：BDNF是新生儿体重的重要影响因素，而且不受LEP，INS的影响。

Abstract:

OBJECTIVE: Recent research has shown that brain-derived neurotrophic factor (BDNF) can improve obesity. This study aimed to explore the relationship between BDNF and birth weight by measuring BDNF levels in the umbilical cord blood of neonates. METHODS: Based on birth weight, 51 first-born full-term healthy neonates were classified into 3 groups: small for gestational age (SGA, n=8), appropriate for gestational age (AGA, n=31) and large for gestational age (LGA, n=12). Height and birth weight as well as umbilical concentrations of BDNF, leptin, insulin, total cholesterol and triglyceride were determined. RESULTS: BDNF level in the SGA group (19 980.00±5 470.54 pg/mL) was significantly higher than that in the AGA (10 598.00±6 295.71 pg/mL) and LGA (7 508.57±3 767.81 pg/mL) groups (P<0.05). There was no significant difference in the BDNF level between the AGA and LGA groups. Stepwise regression analysis showed that the value of BDNF was negatively correlated with birth weight and BMI of neonates, but had no correlation with leptin and insulin levels. Leptin levels showed positive correlations with birth weight and BMI of neonates. There were no significant differences in total cholesterol and triglyceride levels among the three groups. CONCLUSIONS: BDNF is closely correlated to birth weight but not correlated with leptin and insulin in neonates.