托吡酯对癫癎儿童事件相关电位P300影响的研究

Changes of the event related potential P300 following topiramate treatment in children with epilepsy

摘要:

目的：探讨不同剂量托吡酯对伴中央颞区棘波的良性局灶性癫癎(benign epilepsy of childhood with centrotemporal spikes,BECTS)患儿事件相关电位P300的影响。方法：对30例BECTS患儿在服用托吡酯不同剂量的阶段分为A,B两组,A组是在托吡酯加量至每日2 mg/kg后服药6个月测其P300的潜伏期和波幅,然后此30例病人继续增加托吡酯的量至每日5 mg/kg 后服药6个月后作为B组再测其P300的潜伏期,波幅,比较不同剂量对P300的变化来反映其对认知功能的影响。结果：A组服药前后P300 电位潜伏期波幅比较，差异无显著性(P>0．05)，B组服药前后P300 电位潜伏期波幅比较，差异有显著性(P＜0．01)。结论：托吡酯对癫癎患儿认知功能的影响与用药剂量大小相关联。

Abstract:

OBJECTIVE: The event related potential (ERP-P300) is useful to determine cognitive disturbances. This study examined the changes of ERP-P300 following different dosages of topiramate (TPM) treatment in children with epilepsy in order to investigate the effect of different dosages of TPM on cognitive function. METHODS: Thirty cases of benign childhood epilepsy with centrotemporal spikes (BECTS) were first administered with TPM at a dosage of 2 mg/kg?d for 6 months. Afterwards they received another 6 months of TPM treatment at a dosage of 5 mg/kg?d. ERP-P300 was tested before and after different dosages of TPM treatment. RESULTS: There were no significant differences in the latency and amplitude of ERP-P300 before and after 6 months low dosages of TPM treatment. However, the latency was more prolonged and the amplitude was reduced in the ERP-P300 testing after 6 months high dosage of TMP treatment (P<0.01). CONCLUSIONS: The effect of TPM on cognitive function is related to its dosage in children with epilepsy.