人微小病毒B19感染与儿童特发性血小板减少性紫癜关系的meta分析

Association of human parvovirus B19 infection and childhood idiopathic thrombocytopenic purpura: a meta analysis of Chinese literatures

摘要:

目的：综合分析人微小病毒B19感染与儿童特发性血小板减少性紫癜( ITP)的关系。方法：计算机检索中国期刊全文数据库、万方数据库, 检索时间从1994~2008年，纳入人微小病毒B19感染与儿童ITP关系的病例对照研究，对文献数据进行meta分析。结果：共纳入8个研究,其中病例组516例，对照组246例。meta分析显示人微小病毒B19感染在病例组的表达高于对照组（OR=13.71，95%CI=7.07～26.59，Z=7.75, P<0.01）。结论：人微小病毒B19感染与儿童ITP的发病有密切相关性。［中国当代儿科杂志，2009，11（12）：999-1001］

Abstract:

OBJECTIVE: To study the relationship between human parvovirus B19 infection and childhood idiopathic thrombocytopenic purpura (ITP) by the principle of evidence based medicine. METHODS: Papers related to the relationship between human parvovirus B19 infection and childhood ITP published between 1994 and 2008 were retrieved electronically from the Chinese Journals Full-text Database and the Wanfang Data. These relevant papers on case-control trials were statistically studied by meta analysis. RESULTS: Eight papers that met the inclusion criteria were included for this meta analysis. Five hundred and sixteen cases of childhood ITP and 246 healthy controls were enrolled. The meta analysis showed that the incidence of human parvovirus B19 infection in the ITP group was significantly higher than that in the control group (OR=13.71, 95% CI=7.07-26.59, Z=7.75, P<0.01). CONCLUSIONS: Human parvovirus B19 infection is closely associated with childhood ITP.［Chin J Contemp Pediatr, 2009, 11 (12):999-1001］