不同年龄阶段儿童巨细胞病毒感染的临床表现差异

Differences of clinical manifestations from cytomegalovirus infection in children of various age groups

摘要:

目的：巨细胞病毒感染的研究多集中在围生期新生儿，本研究针对儿童巨细胞病毒感染在不同年龄的临床表现及差异做初步探讨。方法：回顾性分析108例巨细胞病毒感染患儿的临床资料，按年龄分成3组：<6 m组、6~12 m组和>12 m组。结果：各年龄组患儿肝功能损害、黄疸、肺炎、血液系统疾患、合并畸形的发生率差异均有显著性（P＜0.05或0.01）。<6 m组主要表现为肝功能损害（83%）、肺炎（47%）、黄疸（43%），其中黄疸型肝炎和无黄疸型肝炎比例相当；血液系统疾患少见，仅占6%。6~12 m组主要表现为肝功能损害（86%）、肺炎（33%）、血液系统疾患（20%），无黄疸型肝炎为主。>12 m组主要表现为肝功能损害（52%）、血液系统疾患（33%），黄疸和肺炎少见。结论：巨细胞病毒感染的靶器官损伤与患儿年龄密切相关。［中国当代儿科杂志，2010，12（1）：21-23］

Abstract:

OBJECTIVE: Newborns have been the focus group for most studies of cytomegalovirus infection. The objective of the study is to share some preliminary analysis on clinical manifestation differences resulting from cytomegalovirus infection in children of various age groups. METHODS: The clinical data of 108 children with cytomegalovirus infection were retrospectively reviewed. The children were classified into three age groups: <6 months, 6-12 months and >12 months. The differences in clinical manifestations from cytomegalovirus infection among the three age groups were identified. RESULTS: Each age group carried distinctive differences in the occurrence of hepatic damage, jaundice, pneumonia, and hematological manifestations, as well as incidence rate of malformation (P<0.05 or 0.01). The primary clinical manifestations of group<6 months old were hepatic damage(83%), pneumonia(47%) and jaundice (43%). There was a similar proportion of anicteric-hepatitis and icteric-hepatitis; however a low incidence rate of hematological disease (6%) was found in group<6 months old. The primary clinical manifestations of group 6-12 months old were hepatic damage (86%), mostly with no presence of jaundice, pneumonia (33%), and hematological disease (20%). Hepatic damage (52%) and hematological disease (33%) were leading clinical symptoms in group>12 months old where jaundice and pneumonia were rare events. CONCLUSIONS: End-organ damage triggered by cytomegalovirus infection is related to the age of the affected children closely.［Chin J Contemp Pediatr, 2010, 12 (1):21-23］