2007～2008年温州地区急性呼吸道感染病毒病原学研究

Viral etiology of acute respiratory infection in children from Wenzhou between 2007 and 2008

摘要:

目的：分析2007~2008年温州地区急性呼吸道感染病毒病原学的检测结果，为临床提供病毒病原学诊断依据。方法：取5 097例急性呼吸道感染儿童鼻咽分泌物,采用直接免疫荧光法检测7种常见呼吸道病毒抗原。结果：①2 209份标本（43.3%）病毒病原检测阳性，其中呼吸道合胞病毒（RSV）1 725例（78.1%），腺病毒（ADV） 61例（2.8%），流感病毒A型（IVA）66例（3.0%），流感病毒B型（IVB）12例（0.5%），副流感病毒1型（PIV1）38例（1.7%），副流感病毒2型（PIV2）7例（0.3%），副流感病毒3型（PIV3）275例（12.4%）；②病毒检出率在小于3个月和小于6个月年龄组较高，分别为53.6% 和49.2%；③冬季病毒检出率最高。结论：2007～2008年温州地区急性呼吸道感染的病毒仍以RSV为主要病原体, ＜6个月的婴幼儿病毒感染率较高，好发于冬季。［中国当代儿科杂志，2010，12（1）：32-34］

Abstract:

OBJECTIVE: To study the viral etiology of acute respiratory infection (ARI)in children from Wenzhou, Zhejiang between 2007 and 2008. METHODS: The nasopharyngeal aspirate samples were obtained from 5 097 hospitalized children with ARI. Seven common respiratory viruses, including respiratory syncytial virus (RSV), influenza virus A and B, parainfluenza viruses 1, 2 and 3 and adenovirus, were detected using direct immunofluorescence. RESULTS: Viral agents were identified in 2 209 cases (43.3%).Of the 2 209, RSV was the most frequent (78.1%), followed by parainfluenza 3 (12.4%), influenza virus A (3.0%), adenovirus (2.8%), parainfluenza 1 (1.7%), influenza B (0.5%) and parainfluenza 2 (0.3%). The infants at ages of <3 months and <6 months had higher detection rate of viruses (53.6% and 49.2%, respectively). A highest detection rate of viruses was found in winter. CONCLUSIONS: RSV is the leading pathogen of ARI in children from Wenzhou, Zhejiang between 2007 and 2008. The children at age of less than 6 months are susceptible to respiratory viruses. The viral activity peaks in winter.［Chin J Contemp Pediatr, 2010, 12 (1):32-34］