多巴胺D2受体基因/ANKK1TaqIA多态性与小婴儿气质

DRD2/ANKK1 Taq IA polymorphism and early infant temperament

摘要:

目的：探讨多巴胺D2受体基因(DRD2)/含锚蛋白重复和激酶域 1 Taq IA基因（ANKK1Taq IA）（rs1800497）多态性与小婴儿气质是否存在关联。方法：采用聚合酶链反应连接酶检测（PCR-LDR）多态性分析技术，检测了长沙市149 名汉族婴儿的Taq IA基因多态性;用小婴儿气质问卷（EITQ）在婴儿出生后1～4月(平均年龄2.75月)时测查其气质（母亲填写）；根据TaqIA多态性等位基因片段大小分为C/C型、T/T型、C/T型。 将气质类型分为含“T” 基因型组（T/T+T/C）和不含“T”基因型组（C/C）进行统计分析。结果：含“T”基因型组和不含“T”基因型组婴儿其气质类型分布差异无显著性，在气质9个维度上的得分差异均无显著性。结论：DRD2/ANKK1TaqIA多态性与小婴儿气质无相关关系。［中国当代儿科杂志，2010，12（2）：106-109］

Abstract:

OBJECTIVE: To investigate whether there is an association between DRD2/ANKK1 Taq IA polymorphism and early infant temperament. METHODS: DRD2/ANKK1 Taq IA polymorphism (rs1800497) was determined using polymerase chain reaction-ligase detection reaction (PCR-LDR) techniques in 149 Chinese Han infants from Changsha City. Their mothers were asked to complete the Early Infant Temperament Questionnaires (EITQ) when the infants were 1 to 4 months old (mean: 2.75 months). There were three genotypes found in these infants: C/C, T/T and C/T. The subjects were subdivided into T-carrier (CT, TT) and non-T-carrier (CC) groups for statistical analysis. RESULTS: There were no differences in the temperament style distribution between the T-carrier and non-T carrier groups. There were also no statistically significant differences between the two groups in the score of the nine temperament dimensions. CONCLUSIONS: DRD2/ANKK1 Taq IA polymorphism is not associated with early infant temperament.［Chin J Contemp Pediatr, 2010, 12 (2):106-109］