儿童热性惊厥发作后急性期海马体积改变的临床研究

Changes in the hippocampal volume in the acute phase following febrile convulsions in children

摘要:

目的：探讨儿童热性惊厥（febrile convulsion，FC）发作后急性期海马体积的变化。方法：对30名FC（15例复杂性，15例单纯性）患儿惊厥发作后48 h内行头颅MRI检查，进行海马体积测量，并与正常儿童比较。结果：对照组右侧海马平均体积较左侧大（P<0.05）。FC组的左右侧海马体积差异无统计学意义。FC组左右侧海马平均体积分别为2.03±0.25 和2.18±0.21 cm3，均较对照组的1.90±0.24 cm3和1.97±0.20 cm3增大（P<0.01）。复杂性FC与单纯性FC患儿左右侧海马体积比较差异无统计学意义。结论：FC发作后急性期海马体积增大；复杂性FC和单纯型FC患儿急性期海马体积改变无明显差异。［中国当代儿科杂志，2010，12（4）：259-261］

Abstract:

OBJECTIVE: To study the changes in the hippocampal volume in the acute phase after febrile convulsions (FC) in children. METHODS: The brain MRI was performed on 30 children with FC (15 simple and 15 complex) and 30 normal children (control). The hippocampal volume for both sides was compared between groups. RESULTS: In the control group, the average volume of the right hippocampus was significantly larger than that of the left side (P<0.05). There was no significant difference in the hippocampal volume between the left and right sides in the FC group. The average volumes of both the left and right hippocampus in the FC group (2.03±0.25 cm3 and 2.18±0.21 cm3 respectively) were enlarged compared to the control group (1.90±0.24 cm3 and 1.97±0.20 cm3 respectively) (P<0.05). There was no significant difference in the hippocampal volume between the simple and the complex FC groups. CONCLUSIONS: The hippocampal volume is enlarged in the acute phase after FC in children. The hippocampal volume in children with simple FC is similar to that in children with complex FC in the acute stage.［Chin J Contemp Pediatr, 2010, 12 (4):259-261］