1~24月婴幼儿胰岛素样生长因子-1水平及与生长发育的关系

Insulin-like growth factor 1 levels and their association with growth and development in infants aged 1-24 months

摘要:

目的：分析1~24月龄婴幼儿血清胰岛素样生长因子-1（IGF-1）水平及其与生长发育的关系。方法：525名健康婴幼儿入选本研究（早产儿125名，足月儿400名），测量体重/身长，酶联免疫吸附法检测血清IGF-1水平。结果：早产组婴儿期血清IGF-1水平在生后1.5月为最低（86±60 ng/mL），此后一直维持较高水平，生后4~12月显著高于足月组。足月组婴儿期血清IGF-1水平在生后1.5月为最高(116±52 ng/mL)，此后缓慢下降，生后8月时降至最低（69±58 ng/mL）。不论是早产儿还是足月儿体重/身长SDS与血清IGF-I水平均存在着正相关关系。结论：血清IGF-1水平均与婴幼儿期生长发育速度密切相关。［中国当代儿科杂志，2010，12（6）：459-461］

Abstract:

OBJECTIVE: To study serum insulin-like growth factor 1 (IGF-1) levels and their association with growth and development in infants aged 1-24 mouths. METHODS: A total of 525 healthy infants (125 preterm, 400 term) were enrolled. Serum IGF-1 levels were measured using ELISA 1.5, 4, 6, 8, 12, 18 and 24 months after birth. The body weight and body length were simultaneously measured. RESULTS: Serum IGF-1 levels were the lowest in preterm infants 1.5 months after birth (86±60 ng/mL). Thereafter, serum IGF-1 levels increased, and were significantly higher than those in term infants between 4 and 12 months after birth. Serum IGF-1 levels in term infants were the highest (116±52 ng/mL) 1.5 months after birth during their life of 12 months old. Thereafter, serum IGF-1 levels decreased and reached to a nadir (69±58 ng/mL) 8 months after birth. IGF-I levels were positively correlated with the weight and the height (SDS) in both preterm and term infants. CONCLUSIONS: Serum IGF-1 levels are closely associated with growth and development in infants.［Chin J Contemp Pediatr, 2010, 12 (6):459-461］