ACE基因插入或缺失多态性与NICU新生儿左心室质量的关系

Relationship between ACE gene insertion or deletion polymorphism and left ventricular mass in newborns admitted to the neonatal intensive care unit

摘要:

目的：探讨新生儿重症监护病房（NICU）新生儿血管紧张素转化酶（ACE）基因型插入/缺失（I/D）多态现象与生后早期左心室质量的关系。方法：72例入住NICU的新生儿纳入研究。生后3 d取末梢血提取DNA，确定ACE基因型，生后1 d进行危重病例评分，并在生后1~3 d进行超声心动检查。结果：72例新生儿中，DD基因型11例，ID基因型31例，II基因型30例， 3基因型间临床特征、出生情况、体格测量及病情轻重差异均无统计学意义。DD基因型的左心室质量指数（LVMI）（29±4 g/m2）显著低于ID＋II基因型 (35±8 g/m2)（t＝2.383，P<0.05）。结论：ACE基因型不同LVMI有显著差异，表现为DD基因型携带者的LVMI显著低于ID＋II基因型携带者，提示D等位基因与左心室肌肉生长发育有相关性。［中国当代儿科杂志，2010，12（10）：767-770］

Abstract:

OBJECTIVE: To study the relationship between angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and left ventricular mass (LVM) in newborns admitted to the neonatal intensive care unit (NICU). METHODS: Seventy-two newborns admitted to the NICU were enrolled. ACE genotypes were determined by genomic DNA which was isolated from heel-prick blood. Disease status of the newborns was evaluated by the Neonatal Critical Score (draft) on postnatal day 1. LVM and LVM index (LVMI) were evaluated by echocardiography on postnatal days 1-3. RESULTS: DD genotype was identified in 11 cases, ID genotype in 31 cases, and II genotype in 30 cases. There were no significant differences in clinical characteristics, critical score and body measurements in newborns with different genotypes. The DD genotype group showed significantly lower LVMI than the group with ID＋II genotypes (29±4 g/m2 vs 35±8 g/m2; P<0.05). CONCLUSIONS: ACE gene polymorphism is associated with the LVMI in newborns admitted to the NICU. The LVMI of DD genotype carriers is significantly lower than that of ID＋II genotypes carriers, which suggests that D allele may be associated with the growth and development of left ventricular.［Chin J Contemp Pediatr, 2010, 12 (10):767-770］