新型甲型H1N1流感患儿消化系统表现

Digestive system manifestations in children infected with novel influenza A (H1N1) virus

摘要:

目的：研究新型甲型H1N1流感患儿消化系统表现。方法：对深圳市儿童医院2009年11月至2010年1月因新型甲型H1N1流感住院的153例患儿及其中有消化系统表现的69例患儿进行前瞻性调研，对其临床特征及转归进行总结。结果：在153例住院的新型甲型H1N1流感患儿中，有消化系统表现者69例（45%），其中有胃肠道症状者50例（33%），无胃肠道症状仅有肝功能异常者19例（12%）。有消化道表现患儿出现昏迷、神经系统并发症及肌酸激酶增高的比例、入住PICU及死亡人数均高于无消化道表现的患儿(P<0.05)。除5例患儿死于严重并发症外，其余患儿均痊愈，胃肠道症状一般在1~3 d消失，肝功能多在4~7 d恢复正常。结论：新型甲型H1N1流感患儿消化道表现较常见，有消化道表现的患儿神经系统受累比无消化道表现的甲型H1N1流感患儿更多见，应该引起临床医生关注。［中国当代儿科杂志，2010，12（10）：793-795］

Abstract:

OBJECTIVE: To study the digestive system manifestations in children infected with novel influenza A (H1N1) virus. METHODS: A prospective study of 153 children infected with novel influenza A (H1N1) virus in Shenzhen children′s Hospital from November 2009 to January 2010 was conducted. The clinical features and outcomes of 69 children with digestive system manifestations were analyzed. RESULTS: The children presenting with digestive system manifestations accounted for 45% (69 cases) in the 153 hospitalized children with novel influenza A (H1N1) infection. Gastrointestinal manifestations were observed in 50 cases (33%) and liver function abnormality in 19 cases (12%). The incidence rate of coma, neurological complications, increase in creative kinase level, ICU admission, and death in the patients with digestive system manifestations were significantly higher than those without digestive system manifestations (P<0.05). In the 69 patients with digestive system manifestations, 5 died from severe complications and 64 recovered fully. Gastrointestinal manifestations disappeared through 1 to 3 days and abnormal liver function recovered through 4 to 7 days. CONCLUSIONS: Digestive system manifestations are common in children infected with novel influenza A (H1N1) virus. Neurological system involvements are more common in the patients with digestive system manifestations than those without.［Chin J Contemp Pediatr, 2010, 12 (10):793-795］