慢性肺疾病患儿外周血细胞因子的改变

Levels of cytokines in peripheral blood of premature infants with chronic lung disease

摘要:

目的：观察早产儿慢性肺疾病外周血白细胞介素(IL)-1β、IL-6、IL-8和肿瘤坏死因子-α（TNF-α）的表达，探讨免疫因素在慢性肺疾病中的可能作用。方法：26例住院满28 d的早产儿分为慢性肺疾病组（14例）和非慢性肺疾病组（对照组，12例），用液相芯片技术（Bio-plex悬浮蛋白芯片系统）检测两组患儿外周血中IL-1β、IL-6、IL-8、TNF-α的表达水平。结果：慢性肺疾病组患儿外周血的IL-1β、IL-6、IL-8、TNF-α与对照组差异均无统计学意义，P>0.05。结论：外周血中的IL-1β、IL-6、IL-8、TNF-α在慢性肺疾病的非急性期没有发生很大的改变，免疫因素可能不在慢性肺疾病的非急性期起作用。［中国当代儿科杂志，2010，12（11）：855-857］

Abstract:

OBJECTIVE: This study examined the levels of interleukin (IL)-1β, IL-6, IL-8 and tumor necrosis factor alpha (TNF-α) in peripheral blood of premature infants with chronic lung disease (CLD) in order to investigate the possible role of immunologic factors in CLD. METHODS: Twenty-six premature infants who had been admitted to the neonatal intensive care unit for 28 days were classified into CLD (n=14) and non-CLD (control, n=12) groups. IL-1β, IL-6, IL-8 and TNF-α concentrations in peripheral blood were measured by multiplex technique (Bio-plex). RESULTS: There were no significant differences in peripheral blood levels of IL-1β, IL-6, IL-8 and TNF-α between the two groups. CONCLUSIONS: There are no significant changes in peripheral blood levels of IL-1β, IL-6, IL-8 and TNF-α in premature infants with CLD on the non-acute phase. Immunologic factors might not play a key role in CLD on the phase.［Chin J Contemp Pediatr, 2010, 12 (11):855-857］