新生儿早期血清雌二醇水平与肺透明膜病及支气管肺发育不良的相关性初探

Relationship between serum estradiol levels in the early postnatal period and the occurrence of hyaline membrane disease and bronchopulmonary dysplasia in neonates

摘要:

目的：检测新生儿早期血清雌二醇（E2）水平的变化规律，探讨其与新生儿肺透明膜病（HMD）、支气管肺发育不良（BPD）发病的相关性。方法：以26周≤胎龄≤32周早产儿59例为研究对象，并设置37周≤胎龄≤42周足月儿61例为对照组，检测生后第1、3、7天的血清雌二醇水平。结果：（1）两组新生儿生后血清E2水平迅速降低，生后第1天、第3天以及第7天间血清E2水平差异有统计学意义。（2）两组新生儿生后第1、3、7天的血清E2水平差异无统计学意义。（3）HMD早产儿血清E2水平与无HMD早产儿比较差异无统计学意义； BPD早产儿生后第3天血清E2水平高于无BPD患儿，而第1、7天的差异无统计学意义。结论：（1）早产儿与足月儿生后血清E2水平在生后7 d内迅速下降；（2）出生后新生儿早期血清E2水平与HMD及BPD无显著相关性，即该激素在新生儿早期不能作为HMD及BPD发病的预测指标。［中国当代儿科杂志，2010，12（11）：864-866］

Abstract:

OBJECTIVE: This study examined the changes of serum levels of estradiol during the early postnatal period in neonates in order to investigate the possible relationship between the serum estradiol levels and the occurrence of pulmonary hyaline membrane disease (HMD) and bronchopulmonary dysplasia (BPD). METHODS: Fifty-nine premature infants with the gestational age between 26 and 32 weeks and 61 full-term infants with the gestational ages between 37 and 42 weeks were enrolled. Serum levels of estradiol were measured on postnatal days 1, 3 and 7. RESULTS: Serum levels of estradiol decreased rapidly after birth in both premature and term infants and there were significant differences among different postnatal ages groups. However, there were no significant differences in the serum estradiol levels between the premature and term groups on postnatal days 1, 3 and 7. Serum estradiol levels measured in premature infants with HMD were not statistically different from those in premature infants without HMD on all time points. Serum estradiol levels in premature infants with BPD were higher than those in premature infants without BPD on postnatal day 3, but there were no noticeable differences on postnatal days 1 and 7. CONCLUSIONS: Serum estradiol levels decline rapidly within 7 days after birth in both premature and term infants. Serum estradiol levels in the early postnatal period are not associated with the occurrence of HMD and BPD, suggesting that serum estradiol in the early postnatal period can not be used as a marker for predicting the development of HMD and BPD.［Chin J Contemp Pediatr, 2010, 12 (11):864-866］