儿童急性淋巴细胞白血病血清IGF-1和IGFBP-3表达变化及其意义

Serum levels of insulin-like growth factor-1 and growth factor binding protein-3 in children with acute lymphocytic leukemia

摘要:

目的：探讨急性淋巴细胞白血病（ALL）患儿血清中胰岛素样生长因子-1（IGF-1）、胰岛素样生长因子结合蛋白-3（IGFBP-3）水平的表达变化及其临床意义。 方法：36例ALL患儿分别在治疗前和完全缓解后6个月留取血清, 对照组血清来自30例外科疾病患儿。应用放射免疫法（RIA）测定IGF-1和免疫放射法（IRMA）测定IGFBP-3水平。结果：ALL组治疗前血清IGF-1、IGFBP-3水平分别为19±4 ng/mL和1216±132 ng/mL，低于对照组的IGF-1、IGFBP-3水平（分别为32±3 ng/mL、2104±191 ng/mL）, 差异有统计学意义（P0.05）。结论：ALL患儿血清IGF-1和IGFBP-3水平降低，并随着病情缓解而升高。提示IGF-1和IGFBP-3可能可以作为儿童ALL诊断及疗效判断的有效指标。

Abstract:

OBJECTIVE: To study serum levels and clinical significance of insulin-like growth factor-1 (IGF-1) and growth factor binding protein 3 (IGFBP-3) in children with acute lymphocytic leukemia (ALL). METHODS: Serum samples were obtained from 36 children with ALL before treatment and 6 months after complete remission. Thirty children with surgical diseases severed as the control group. Serum IGF-1 levels were measured using radioimmunoassay (RIA). Serum IGFBP-3 levels were measured using immunoradioassays (IRMA). RESULTS: Serum levels of IGF-1 and IGFBP-3 in the ALL group were 19±4 ng/mL and 1216±132 ng/mL, respectively before treatment, which were lower than those in the control group (32±3 ng/mL and 2104±191 ng/mL respectively) (P<0.01). Serum levels of IGF-1 and IGFBP-3 in the ALL group increased to 30±3 ng/mL and 1941±164 ng/mL respectively 6 months after complete remission, which were significantly higher than those before treatment (P<0.01) and were similar to the levels of the control group. CONCLUSIONS: Serum levels of IGF-1 and IGFBP-3 are reduced in children with ALL, but increase significantly after complete remission, suggesting that IGF-1 and IGFBP-3 might serve as useful markers for the diagnosis and evaluation of therapeutic effects of childhood ALL.