超敏C-反应蛋白和胰岛素敏感指数在儿童阻塞性睡眠呼吸暂停综合征中的变化

Changes of high-sensitivity CRP and insulin sensitivity index in children with obstructive sleep apnea hypopnea syndrome

摘要:

目的：探讨阻塞性睡眠呼吸暂停综合征（OSAHS）患儿超敏C-反应蛋白（hsCRP）和胰岛素敏感指数（ISI）的变化。方法：51例患儿分为 OSAHS组（29例）和原发性鼾症（PS）组（22例）。均实施多导睡眠监测仪（PSG）检测，分别测体重指数（BMI）、hsCRP、血脂、空腹血糖(FPG)、空腹胰岛素(INS)，计算ISI。结果：与 PS 组比较，OSAHS组的呼吸暂停通气指数（AHI）增高（13.2±9.2 vs 1.2±1.1, P<0.05）；OSAHS组的最低血氧饱和度（LSaO2）低于PS患儿［(78.5±5.4)% vs (87.4±3.7)%, P<0.05］；OSAHS组的hsCRP高于PS组（2.8±2.7 mg/L vs 0.6±0.9 mg/L,P<0.05）；OSAHS组的ISI、血脂与 PS 组的差异无统计学意义。OSAHS 组的hsCRP与LSaO2呈负相关（r=-0.531, P<0.05）。结论：OSAHS患儿hsCRP水平增高，可能与日后心血管疾病的发生相关，应早期给予干预。

Abstract:

OBJECTIVE: To investigate the levels of highsensitivity CRP (hsCRP) and insulin sensitivity index (ISI) in children with obstructive sleep apnea hypopnea syndrome (OSAHS). METHODS: Twenty-nine children with OSAHS and 22 children with primary snoring (PS) were enrolled. Polysomnography was performed. Body mass index (BMI), hsCRP, serum lipids, fasting plasma glucose (FPG), and insulin (INS) were measured. ISI was calculated. RESULTS: The apnea hypopnea index (AHI) in the OSAHS group was higher than that in the PS group (13.2±9.2 vs 1.2±1.1; P<0.05). The lowest oxygen saturation (LSaO2) in the OSAHS group was lower than that in the PS group ［(78.5±5.4)% vs (87.4±3.7)%; P<0.05］. The values of hsCRP in the OSAHS group was higher than those in the PS group (2.8±2.7 mg/L vs 0.6±0.9 mg/L; P<0.05). There were no significant differences in the ISI and serum lipids between the two groups. The hsCRP level was negatively correlated with LSaO2 in the OSAHS group (r=-0.531, P<0.05). CONCLUSIONS: The hsCRP level increases in children with OSAHS. The increased hsCRP level might be associated with an increased risk of cardiovascular diseases.