利培酮在治疗孤独症儿童行为问题中的作用

Treatment of behavioral disorders by risperidone in children with autism

摘要:

目的：研究利培酮在治疗孤独症儿童行为问题中的作用。方法：选取40例5～12岁具有行为问题的孤独症儿童，给予8周的利培酮治疗，在治疗前后进行临床疗效总评量表（CGI）和孤独症治疗评估量表(ATEC)评分，并观察利培酮治疗的不良反应。结果：利培酮治疗后第8周末的病情严重程度、ATEC总分均低于治疗前，且耐受性好；其中在ATEC评分中，除了社交评分在治疗前后无明显改变之外，言语、感知和行为评分均得到明显的改善。结论：利培酮可以显著地改善孤独症儿童的行为问题且具有良好的耐受性。

Abstract:

OBJECTIVE: To study the effect of risperidone treatment on behavioral disorders in children with autism. METHODS: Forty children with behavioral disorders (aged from 5 to 12 years) were treated with risperidone for 8 weeks. The behavioral symptoms were evaluated by the Clinical Global Impression (CGI) and the Autism Treatment Evaluation Checklist (ATEC) before and after the treatment. The adverse events related to risperidone treatment were observed. RESULTS: The score of severity of illness and the ATEC total scores were significantly reduced 8 weeks after risperidone treatment. Besides the social intercourse ability, great improvements have been shown on the verbal communication, apperception and behavioural symptoms by the ATEC. No severe adverse events related to risperidone treatment were observed. CONCLUSIONS: Risperidone can significantly improve the behavioral disorders in children with autism and is well-tolerated.