支气管哮喘儿童血清25-（OH）D3和总免疫球蛋白E的变化

Serum levels of 25-(OH)D3 and total IgE in children with asthma

摘要:

目的：研究支气管哮喘儿童血清25-羟维生素D3［25-（OH）D3］和总免疫球蛋白E（TIgE）的变化及临床意义。方法采用放射免疫分析法，检测30例支气管哮喘、40例喘息性支气管炎患儿及40例正常对照儿童血清25-（OH）D3及TIgE含量，比较3组间其血清含量的差异。结果支气管哮喘组血清25-（OH）D3含量（18±3 ng/mL）明显低于喘息性支气管炎组（43±3 ng/mL）和正常对照组（43±3 ng/mL），且TIgE含量（192±16 IU/mL）明显高于喘息性支气管炎组（123±14 IU/mL）和正常对照组（118±15 IU/mL），差异均有统计学意义（P＜0.01）。支气管哮喘组血清25-（OH）D3与TIgE呈负相关（r=-0.783，P＜0.01＝，喘息性支气管炎组、正常对照组血清25-（OH）D3与TIgE均无相关性。结论血清25-（OH）D3缺乏可能是导致儿童支气管哮喘发作的原因。血清25-（OH）D3水平增高可以抑制IgE的过度表达，这可能成为预防和治疗支气管哮喘等过敏性疾病的一种新的有效途径。

Abstract:

OBJECTIVE: To study the changes and clinical significance of serum levels of 25-(OH)D3 and total IgE in children with asthma. METHODS: Thirty children with asthma, 40 children with asthmatic bronchitis, and 40 healthy children were enrolled. Double-antibody radioimmunoassay was used to detect the levels of serum 25-(OH)D3 and total IgE. RESULTS: Serum 25-(OH)D3 levels (18±3 ng/Ml)decreased significantly in the asthmatic group compared with those in the asthmatic bronchitis group (43±3 ng/mL) and the control group (43±3 ng/mL) (P＜0.01). In contrast, serum total IgE levels (192±16 IU/mL) increased significantly in the asthmatic group compared with those in the asthmatic bronchitis group (123±14 IU/mL) and the control group (118±15 IU/mL) (P<0.01). Serum 25-(OH)D3 levels were negatively correlated with serum total IgE levels in asthmatic children (r=-0.783, P<0.01). There were no correlation between serum 25-(OH)D3 levels and serum total IgE level in the asthmatic bronchitis and the control groups. CONCLUSIONS: 25-(OH)D3 may play an important role in the pathogenesis of asthma. The increased serum 25-(OH)D3 level may inhibit total IgE expression, suggesting that increasing serum 25-(OH)D3 level might be a new option for the prevention and treatment of asthma.