儿童原发性肾病综合征血清酰化刺激蛋白及补体C3水平的变化

Levels of serum acylation-stimulating protein and C3 in children with primary nephrotic syndrome

摘要:

目的：观察原发性肾病综合征（PNS）患儿血清酰化刺激蛋白（ASP）、补体C3水平的变化以及与血脂的关系。方法：分别检测35例未经治疗的PNS患儿（蛋白尿组）和25例缓解期PNS患儿（缓解组）空腹血清ASP、C3、白蛋白及血脂水平，并与35例体重指数相匹配的正常儿童（对照组）进行比较。结果：蛋白尿组血清ASP水平（101±22 nmol/L）高于缓解组（32±8 nmol/L）及对照组（33± 8 nmol/L）（P＜0.01），而血清C3水平在3组之间差异无统计学意义。蛋白尿组血清总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白（LDL）、载脂蛋白B（apoB）水平明显升高，血清白蛋白（ALB）水平明显降低，与缓解组和对照组比较，差异有统计学意义（P0.05）。结论：PNS患儿血清ASP水平升高，推测与机体对抗高脂血症有关。

Abstract:

OBJECTIVE: To study serum acylation-stimulating protein (ASP) and complement 3 (C3) levels and their relationship with blood lipids in children with primary nephrotic syndrome (PNS). METHODS: Blood samples were obtained from 35 PNS children with proteinuria, 25 children with PNS at remission and 35 body mass index-matched healthy children (control group). Fasting serum ASP, C3, albumin and blood lipids were measured. RESULTS: The serum ASP levels in the proteinuria group (101±22 nmol/L) were significantly higher than those in the remission group (32±8 nmol/L) and the control group (33± 8 nmol/L) (P0.05). CONCLUSIONS: The increased serum ASP level may be associated with a complemental mechanism against hyperlipidemia in children with PNS.