促红细胞生成素治疗新生儿缺氧缺血性脑病疗效观察

Therapeutic effects of erythropoietin on hypoxic-ischemic encephalopathy in neonates

摘要:

目的：通过对促红细胞生成素（EPO）治疗中度、重度新生儿缺氧缺血性脑病（HIE）的疗效观察，了解EPO对神经的保护作用及对新生儿HIE预后的影响。方法：将70例中、重度HIE新生儿随机分为治疗组（35例）和对照组（35例），其中治疗组中度HIE 22例，重度HIE 13例；对照组中度HIE 24例，重度HIE 11例；同时选取同一时期健康足月儿35例作为正常组。对照组给予常规治疗。除常规治疗外，治疗组给予静脉注射EPO 每日200 IU/kg，每周3次，每6 d查血常规1次，根据血常规结果调整EPO剂量,总疗程为2～4周。所有患儿于28日龄时进行NBNA评分，3月、6月龄时进行智能发育测评（CDCC）。结果：治疗组28日龄NBNA评分正常者比例高于对照组(P<0.05),但仍低于正常组(P<0.01)。3月龄CDCC评分（包括MDI、PDI评分）治疗组正常者比例高于对照组（P<0.05）,但低于正常组（P<0.01）。6月龄CDCC评分治疗组正常者比例高于对照组(P<0.05), 治疗组MDI评分正常者比例与正常组相比较，差异无统计学意义，但PDI评分正常者比例仍低正常组(P<0.05)。结论：EPO可保护因缺氧缺血损害的神经细胞，促进中、重度HIE新生儿大脑发育。

Abstract:

OBJECTIVE: To study the efficacy of erythropoietinin (EPO) in the treatment of moderate or severe hypoxic-ischemic encephalopathy (HIE) in neonates. METHODS: Seventy neonates with moderate or severe HIE were randomly assigned to two groups: EPO treatment and control (n=35 each). The EPO treatment group included 22 cases of moderate HIE and 13 cases of severe HIE. The control group included 24 cases of moderate HIE and 11 cases of severe HIE. Thirty-five healthy full-term infants served as normal group. The control group received a conventional treatment. Beside the conventional treatment, the EPO treatment group was intravenously injected with EPO of 200 IU/kg?d, 3 times weekly. Routine blood test was performed every 6 days. EPO dose was adjusted based on the results of the routine blood test. The course of EPO treatment was 2 to 4 weeks. Neonatal Behavioral Neurological Assessment (NBNA) was performed at age of 28 days. The infant development test of Child Development Centre of China (CDCC) was performed at ages of 3 months and 6 months. RESULTS: The percentage of normal NBNA scores in the EPO treatment group was significantly higher than that in the control group at age of 28 days (P<0.05), but was significantly lower than that in the normal group (P<0.01). The CDCC test including physical development index (PDI) and physical development index (MDI) showed the percentage of normal results in the EPO treatment group was significantly higher than in the control group at age of 3 months (P<0.05), but was significantly lower than in the normal group (P<0.01). The CDCC test including PDI and MDI showed that the percentage of normal results in the EPO treatment group was significantly higher than in the control group at age of 6 months. The MDI test results in the EPO treatment group were not significantly different from those in the normal group at age of 6 months, but the percentage of normal results in the PDI test in the EPO treatment group was still significantly lower than that in the normal group (P<0.05). CONCLUSIONS: EPO treatment has neuroprotective effects against moderate or severe HIE and improves longterm behavioral neurological developments in neonates.