新生儿窒息多器官功能损害的危险因素分析

Risk factors of post-asphyxial multiple organ dysfunction in neonates

摘要:

目的：探讨新生儿窒息多器官功能损害的危险因素，为预防窒息后新生儿多器官功能损害提供理论依据。方法：2009年1月至2010年12月窒息患儿共397例，其中合并多器官功能损害患儿179例作为观察组，无多器官损害患儿218例为对照组，回顾性分析影响新生儿窒息后多器官功能损害的危险因素。 结果：多因素logistic 回归分析显示：重度窒息、宫内窘迫、异常分娩、羊水减少为新生儿窒息后多器官功能损害的独立危险因素。经Spearman秩相关发现，受累器官个数随入院日龄的增加而增多（P<0.05），随胎龄、出生体重的降低而增多（均P<0.05）。结论：临床上应加强围产期监护，特别要重视对早产儿和低出生体重儿的监护，从而降低多器官功能损害的发生率。

Abstract:

OBJECTIVE: To investigate the risk factors related to post-asphyxial multiple organ dysfunction (PA-MOD) in neonates. METHODS: A total of 397 neonates with birth asphyxia were enrolled from January 2009 to December 2010.The patients were divided into PA-MOD group (n=179) and non-PA-MOD group (n=218). The risk factors of PA-MOD were retrospectively studied. RESULTS: Multivariate logistic regression analysis showed that severe asphyxia, fetal distress, abnormal labor, and decreased amniotic fluid were the risk factors for PA-MOD among the neonates. Spearman rank correlation analysis showed that the number of the involved organs increased along with the increase of age at admission (P<0.05) and with the decrease of gestational age and birth weight (P<0.05). CONCLUSIONS: The efforts should be made to enhance perinatal care for neonates, especially for preterm infants and low-birh-weight infants, to decrease the incidence of MOD.