口服双歧杆菌对极低出生体重儿免疫功能的影响

Effects of bacillus bifidus supplementation on the immunity in very-low-birth-weight infants

摘要:

目的：探讨口服双歧杆菌对极低出生体重儿免疫功能的影响。方法：将50例住院极低出生体重儿随机分为观察组和对照组（n=25）。观察组在一般治疗的基础上给予口服双歧杆菌14 d，观察临床指标和外周血相关免疫学指标。结果：观察组需生理盐水灌肠次数较对照组明显减少(P0.05)。观察组外周血CD4+T细胞比例和CD4+/CD8+比值高于对照组(P0.05)；观察组外周血IgA水平高于对照组(P0.05)。结论：双歧杆菌可以改善极低出生体重儿的消化道症状，促进极低出生体重儿免疫功能的成熟和发展。

Abstract:

OBJECTIVE: To study the effect of bacillus bifidus supplementation on the immunity in very-low-birth-weight (VLBW) infants. METHODS: Fifty VLBW infants who were hospitalized in the neonatal intensive care unit were equally randomized into observed and control groups. The observed group received bacillus bifidus for 14 days after birth in addition to the conventional management, which was applied in the control group. The clinical indicators and relevant immunological parameters in the peripheral blood were observed. RESULTS: The times required for brine enema was significantly fewer in the observed group than in the control group (P0.05). In the observed group, the proportions of CD4+ T lymphocytes and the CD4+/CD8+ ratio increased, whilst the proportion of CD3+ and CD8+ T lymphocytes showed no significant change. The levels of immunoglobulin A in the peripheral blood increased in the observed group, while the levels of immunoglobulin M and immunoglobulin G were not statistically changed in the observed group when compared with the control group. CONCLUSIONS: Bacillus bifidus can improve gastrointestinal symptoms of VLBW infants and have a positive effect on their immunity.