先天性心脏病患儿血浆脑钠肽水平与左心功能的关系
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R725.4

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Correlation between the blood serum BNP level and the left cardiac function in children with congenital heart disease
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    目的:探讨先天性心脏病(先心病)患儿血浆脑钠肽(BNP)水平与左心功能的相关性及其临床意义。方法:回顾性分析41例先心病患儿的临床资料,根据有无合并充血性心力衰竭(CHF)将其分为2组:一组为合并CHF组(n=21),另一组为无合并CHF组(n=20)。用化学发光免疫分析法测定血浆BNP水平,超声心动图测定左室射血分数(LVEF)。结果:①先心病合并CHF组患儿血浆BNP水平为1353(926,2978)pg/mL,显著高于先心病无合并CHF组[149(75,242)pg/mL](P<0.01);先心病合并CHF组患儿LVEF为60(53,65)%,显著低于先心病无合并CHF组68(64,72)%(P<0.01)。②先心病患儿血浆BNP水平与LVEF呈显著负相关(r=-0.652,P<0.01)。结论:BNP可作为反映左心功能受损的敏感指标,与心功能状态有明显相关性,其检测对先心病合并CHF患儿左心功能的判断具有重要意义。

    Abstract:

    OBJECTIVE: To study the correlation between the blood serum brain natriuretic peptide (BNP) level and the left cardiac function in children with congenital heart disease (CHD). METHODS: The clinical data of 41 CHD children were retrospectively analyzed. Patients were divided into two groups based on the existence of congestive heart failure (CHF): CHD+CHF (n=21) and CHD alone (n=20). The blood serum BNP level was determined using chemiluminescence immunoassay, and the left ventricular ejection fraction (LVEF) was measured with echocardiogram. RESULTS: The serum BNP level was 1353 pg/mL (range: 926-2978) in the CHD+CHF group, which was significantly higher than in the CHD alone group[149 pg/mL (range: 75-242)](P<0.01). The LVEF was 60% (range: 53%-65%) in the CHD+CHF group, which was significantly lower than in the CHD alone group[68% (range: 64%-72%)](P<0.01). The serum BNP level showed a negative correlation with the LVEF level (r=-0.652, P<0.01). CONCLUSIONS: The blood serum BNP level is related to the cardiac function. For children with severe CHD+CHF, serum BNP level can be used as a sensitive indicator for evaluating cardiac function damage.

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张鹤,李玖军.先天性心脏病患儿血浆脑钠肽水平与左心功能的关系[J].中国当代儿科杂志,2012,14(1):42-44

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  • 在线发布日期: 2012-01-15
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