干细胞移植在肾脏疾病中的应用

Application of stem cell transplantation in kidney diseases

摘要:

该文总结干细胞移植在肾脏损伤修复中的治疗证据，着重讨论干细胞种类的选择、移植方法的选择、干细胞抵达肾脏的可能机制和它起效的可能机制。脐带间充质干细胞的应用具有广阔的前景，但细胞移植的途径和最佳剂量仍有待进一步研究。干细胞抵达肾脏的机制可能和靶部位表达和释放趋化干细胞的因子有关，而干细胞的旁分泌和内分泌功能可能是它发挥作用的主要的机制。关于干细胞移植治疗肾脏疾病还有许多问题有待解决，但是干细胞移植仍是急慢性肾脏疾病的治疗中一个充满前景和希望的治疗策略。

Abstract:

This paper summarizes the current literature on the potential therapeutic role of stem cell transplantation for kidney injury and repair and focuses on the choice of types of stem cells, the method of transplantation, and the mechanisms of stem cell homing to injured renal tissues and its protective effects. The application of umbilical cord mesenchymal stem cells (UC-MSCs) shows wide prospects, but the approach and optimal dose of cell transplantation are under intensive investigation. Signals that regulate stem cell homing to injured renal tissues may be related to chemokines or factors released in the target site. Several studies have pointed out that paracrine and endocrine of stem cells are the most likely mechanism of action in the injured nephron. Many questions remain unanswered but stem cell-based therapy is a promising new strategy for acute and chronic kidney diseases.