支气管肺泡灌洗液细菌培养在小儿肺部感染中的应用

Application of bacterial cultures of bronchoalveolar lavage fluids in children with pulmonary infection

摘要:

目的：探讨支气管肺泡灌洗液（bronchoalveolar lavage fluid, BALF）细菌培养在小儿肺部感染中的应用价值。方法：对2008年6月至2011年2月因肺部感染住院的80例患儿的痰和BALF进行普通细菌培养，并对两种标本的培养结果进行比较。结果：80例患儿BALF细菌培养中检出草绿色链球菌72例次（90%），奈瑟氏菌41例次（51%），肺炎链球菌11例次（14%），金黄色葡萄球菌3例次（4%），大肠杆菌3例次（4%）。与痰培养结果比较，BALF中检出草绿色链球菌阳性率差异无统计学意义，但BALF培养中肺炎链球菌阳性率（14%）明显高于痰培养（4%）（P<0.05），且只有BALF培养中检出了大肠杆菌。结论：BALF细菌培养对小儿肺部感染的病原菌明确具有一定作用。由于BALF细菌培养直接取材于病变部位，能为临床提供相对可靠的诊治依据。

Abstract:

OBJECTIVE: To study the value of bacterial cultures of bronchoalveolar lavage fluids (BALF) in children with pulmonary infection. METHODS: Bacterial cultures sampled from both sputum and BALF were performed on 80 hospitalized children with pulmonary infection between June 2008 and February 2011.Culture results between the two samples were compared. RESULTS: In the 80 children with pulmonary infection, bacterial cultures of BALF showed that Viridans Streptococci were found in 72 cases (90%), Neisseria in 41 cases (51%), Streptococcus pneumoniae in 11 cases (14%), Staphylococcus Aureus in 3 cases (4%) and Escherichia coli in 3 cases (4%). The positive rates of Viridans Streptococci in the bacterial cultures of BALF was not significantly different from the bacterial cultures of sputum, but the positive rate of Streptococcus pneumoniae in the bacterial cultures of BALF was significantly higher than in the bacterial cultures of sputum (4%). Moreover, Escherichia coli were found only by bacterial cultures of BALF. CONCLUSIONS: Bacterial cultures of BALF are useful in the identification of pathogenic bacteria for pulmonary infection in children. Due to the samples taken from the lesion regions in bacterial cultures of BALF, the results of may be more reliable.