脑钠肽和氨基末端脑钠尿肽原在儿童心血管疾病诊治中的进展

Research advance of brain natriuretic peptide and N-terminal brain natriuretic peptide in the diagnosis and treatment of pediatric cardiovascular diseases

摘要:

脑钠肽(BNP)和氨基末端脑钠尿肽原(NT-proBNP)是儿童心血管疾病中的重要指标，其水平与儿童的年龄及性别相关。目前的研究表明，BNP与NT-proBNP对于心力衰竭（心衰）具有较高的诊断价值，特异性和敏感性均较高，有助于心衰与单纯性肺源性因素所致急性呼吸困难的鉴别。另外，在肺动脉高压、心肌病和川崎病的患儿中，BNP与NT-proBNP均可以有助于判断病情和指导治疗。目前的局限在于研究样本量相对偏小，检测方法及正常值范围未完全统一。

Abstract:

Brain natriuretic peptide (BNP) and N-terminal brain natriuretic peptide (NT-proBNP) are important biomarkers for pediatric cardiovascular diseases. Peptide levels are associated with age and gender. Current studies have shown that BNP and NT-proBNP are valuable in the diagnosis of heart failure, with a high specificity and sensitivity. They also contribute to differentiating heart failure from acute respiratory distress induced by simple pulmonary factors. In addition, BNP and NT-proBNP are useful in the evaluation of disease severity and treatment guidance in children with pulmonary hypertension, cardiomyopathy and Kawasaki disease. Current limitations include the relatively small sample size of the study, the detection method and a range of normal values that are not completely uniform.