手足口病合并病毒性脑炎患儿血清铁蛋白及神经元特异性烯醇化酶水平的变化及意义

Serum levels of ferritin and neuron-specific enolase in children with hand-foot-mouth disease complicated by acute viral encephalitis

摘要:

目的：探讨手足口病（HFMD）合并病毒性脑炎患儿血清铁蛋白和神经元特异性烯醇化酶（NSE）水平的变化及意义。方法：采用酶联免疫吸附（ELISA）与电化学发光法对20 例HFMD合并病毒性脑炎（脑炎组）和20 例单纯HFMD患儿(单纯HFMD组)进行血清铁蛋白和NSE水平测定,并与20 例正常健康儿(对照组)进行比较。结果：脑炎组血清铁蛋白含量为 212±71 μg /L，明显高于单纯HFMD组（85±18 μg /L）及对照组（70±15 μg/L）（均P＜0.01）；脑炎组血清NSE含量（8.6±2.6 μg/L）亦明显高于单纯HFMD组（6.0±1.3 μg/L）及对照组（5.6±1.8 μg/L），（均P＜0.01）。治疗后脑炎组血清铁蛋白及NSE分别下降至126±37 μg /L、6.8±1.9 μg/L，较治疗前差异有统计学意义（P<0.01）。结论：HFMD合并病毒性脑炎患儿血清铁蛋白和NSE含量显著升高，对血清铁蛋白和NSE含量的检测有利于HFMD合并病毒性脑炎的早期诊断。

Abstract:

OBJECTIVE: To study serum ferritin and neuron-specific enolase (NSE) levels in children with hand-foot-mouth disease (HFMD) complicated by acute viral encephalitis and their clinical significance. METHODS: Serum levels of ferritin and NSE were measured using ELISA and electrochemical luminescence in 20 children with HFMD complicated by viral encephalitis (encephalitis group), 20 children with HFMD only (simple HFMD group) and 20 healthy children (control group). RESULTS: Serum levels of ferritin in the encephalitis group (212±71 μg/L) were significantly higher than in the simple HFMD group (85±18 μg/L) and control group (70±15 μg/L) (P<0.01). Serum levels of NSE in the encephalitis group (8.6±2.6 μg/L) were also significantly higher than in the simple HFMD group (6.0±1.3 μg/L) and control group (5.6±1.8 μg/L) (P<0.01). Significantly decreased serum ferritin (126±37 μg/L) and NSE levels (6.8±1.9 μg/L) were found in the encephalitis group (P<0.01) after treatment. CONCLUSIONS: Serum levels of ferritin and NSE in children with HFMD complicated by acute viral encephalitis increase, suggesting that serum ferritin and NSE measurement is useful in the early diagnosis of HFMD complicated by acute viral encephalitis.