儿童良性黑棘皮病与代谢异常

Childhood benign acanthosis nigricans and metabolic abnormality

摘要:

目的：观察儿童良性黑棘皮病与人体测量指标参数及代谢指标的关系，探讨儿童良性黑棘皮病与代谢性疾病的关系。方法：回顾性分析2007年2月至 2011年10月于我院诊治的29例良性黑棘皮病患儿的临床资料，以同年龄同性别同民族相匹配的32例正常儿童为对照组。比较两组儿童人体肥胖指标（体重指数、腰臀围比、体脂含量及体脂百分比）及代谢指标（血糖、胰岛素水平、血脂系列）等的不同。结果：29例良性黑棘皮病患儿体重指数、体脂含量、体脂百分数、腰臀围比、空腹血糖及胰岛素水平、甘油三酯均高于对照组（P<0.05），而高密度脂蛋白低于对照组（P<0.05）。29例良性黑棘皮病患儿中，16例存在糖耐量异常，3例确诊为糖尿病（1例1型，2例2型）。结论：儿童良性黑棘皮病与肥胖、胰岛素抵抗及血脂异常密切相关。

Abstract:

OBJECTIVE: To observe the relationship of childhood benign acanthosis nigricans to anthropometric and metabolic indexes, with the aim of studying the association between childhood benign acanthosis nigricans and metabolic diseases. METHODS: A retrospective analysis was performed on the clinical data of 29 children who presented with benign acanthosis nigricans between February 2007 and October 2011. Thirty-two age, sex- and ethnic-matched normal children were selected as control group. The two groups were compared according to obesity (body mass index, waist-to-hip ratio, body fat content and body fat percentage) and metabolic indexes (blood glucose, insulin level and blood lipids). RESULTS: Body mass index, body fat content, body fat percentage, waist-to-hip ratio, fasting blood glucose, insulin level and triglyceride in the 29 patients with benign acanthosis nigricans were higher than in the control group (P<0.05), but the level of high-density lipoprotein in the 29 patients was lower than in the control group (P<0.05). Of the 29 patients, 16 had impaired glucose tolerance and 3 were diagnosed with diabetes (1 case with type 1, two cases with type 2). CONCLUSIONS: Childhood benign acanthosis nigricans is closely associated with obesity, insulin resistance and dyslipidemia.