T 淋巴细胞毒相关抗原-４基因49位点多态性与儿童1型糖尿病相关性的Meta分析

Association of cytotoxic T lymphocyte-associated antigen-4+49A/G polymorphism with childhood type 1 diabetes mellitus: a meta-analysis

摘要:

目的：评价T 淋巴细胞毒相关抗原-4（CTLA-4）基因49位点多态性与儿童1型糖尿病（T1DM）的相关性。方法：检索PubMed、EBSCO、中国学术期刊全文数据库（CNKI）、中国生物医学文献数据库（CBM）、万方数据库，收集CTLA-4基因49位点多态性与儿童T1DM相关性的文献。用Meta分析的方法检测CTLA-4基因49位点的基因型和等位基因在儿童T1DM组与对照组中是否有差异。结果：共纳入10篇文献，共有T1DM 1084例，对照组1338例。根据各项研究的异质性检验结果，均利用固定效应模型对CTLA-4基因49位点的AG、GG、GG+AG基因型和G等位基因与T1DM相关性进行Meta分析，各项研究的合并OR值（95% CI）分别为1.13（0.97～1.33）、1.42（1.16～1.75）、1.20（1.03～1.40）、1.21（1.09～1.33），提示T1DM组CTLA-4基因49位点G等位基因和GG、GG+AG基因型表达与对照组比较均有显著差异。结论：CTLA-4基因49位点G等位基因和GG、GG+AG基因型均与儿童T1DM的发生相关。

Abstract:

OBJECTIVE: To evaluate the association of cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) + 49A/G polymorphism with type 1 diabetes mellitus (T1DM) in children. METHODS: Papers about the association of CTLA4+49A/G polymorphism with T1DM in children were collected by searching PubMed, EBSCO, CBM, CNKI, and Wanfang Data. A meta-analysis was performed to examine differences in the genotypes (AG, GG, and GG+AG) and G allele at position 49 of the CTLA-4 gene between a childhood T1DM group and a control group. RESULTS: A total of 10 papers involving 1084 T1DM children and 1338 healthy children were included. The Meta-analysis was performed to evaluate the association of the genotypes (AG, GG, and GG+AG) and the G allele at position 49 of the CTLA-4 gene with T1DM using a fixed effect model according to the heterogeneity test results of all studies. The pooled OR values (95% CI) were 1.13 (0.97-1.33), 1.42 (1.16-1.75), 1.20 (1.03-1.40), and 1.21 (1.09-1.33), suggesting a significant difference in genotypes (AG, GG, and GG+AG) and the G allele at position 49 of the CTLA-4 gene between the two groups. CONCLUSIONS: CTLA-4 +49A/G polymorphism is associated with T1DM in children.