人神经前体细胞移植治疗重度脑瘫患儿疗效观察
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R651

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Treatment of cerebral palsy with transplantation of human neural progenitor cells
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    摘要:

    目的:观察人神经前体细胞(human neural progenitor cells, hNPCs)移植治疗重度脑性瘫痪(cerebral palsy, CP)患儿的临床疗效。方法:45例重度CP患儿自愿接受hNPCs移植治疗。取孕10~12周人胚胎脑细胞,经体外培养扩增为人神经干细胞球,在超声引导下经侧脑室穿刺注入患儿脑室。49例接受常规康复治疗的重度CP患儿作为对照组。结果:移植后疗效最早出现的1例患儿于术后3 d睡眠、激惹、肌张力明显改善,大部分患儿于术后1个月出现明显改善,3~6个月疗效逐渐减缓。移植组患儿术后1年粗大运动、精细动作及认知发育水平均明显优于对照组。移植治疗后无1例患儿出现危及生命或导致患儿生活质量较术前下降的并发症,移植5年以上随访未见肿瘤发生。结论:hNPCs移植治疗重度CP是一种新的、安全有效的方法,值得进一步研究探索。

    Abstract:

    OBJECTIVE: To study the clinical efficacy of transplantation of human neural progenitor cells (hNPCs) in the treatment of severe cerebral palsy (CP) in children. METHODS: Forty-five children with CP were voluntarily accepted transplantation of hNPCs. The cells obtained from the forebrain of 10 to 12-week-fetus were cultured and amplified into hNPCs. Then the hNPCs were injected into the cerebral ventricle of the patients with the supersonic guidance. RESULTS: Dyssomnia, irritability and muscular tension were improved in one patient 3 days after transplantation. The clinical improvements were observed in the majority of the patients 1 month after transplantation. The therapeutic effects slowed down 3 to 6 months after transplantation. One year after transplantation the gross and fine motor skills and the congnition ability in the transplantation group were considerably surpassed to those in the control group. No delayed severe complications were observed after transplantation. No tumorigenesis was noted 5 years after transplantation. CONCLUSIONS: The transplantation of hNPCs as a novel therapy is effective and safe for severe CP. Many investigations are needed to evaluate the effect of the therapy.

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刘卫鹏,屈素清,栾佐,龚小军,汪兆艳.人神经前体细胞移植治疗重度脑瘫患儿疗效观察[J].中国当代儿科杂志,2012,14(10):759-762

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  • 在线发布日期: 2012-10-15
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