血清25-羟维生素D在佝偻病诊断中的应用价值

Role of serum 25-hydroxyvitamin D in the diagnosis of vitamin D deficiency rickets

摘要:

目的：探讨血清25羟维生素D［25（OH）D］在维生素D缺乏性佝偻病早期诊断中的意义。方法：检测对照组（73例）、可疑组（45例）和佝偻病组（65例）的血清25（OH）D、钙、磷、碱性磷酸酶浓度，并通过ROC曲线对血清25（OH）D的诊断价值进行评价。结果：对照组、可疑组和佝偻病组的血清25（OH）D水平分别为112±37、83±30和72±31 nmol/L，后两者均显著低于对照组（F=26.174，P0.05）。可疑组和佝偻病组的维生素D缺乏率均显著高于对照组（χ2=33.346， P0.05）。结论：血清25(OH)D水平在可疑及确诊佝偻病的患儿中显著降低，可以反映维生素D的营养状况，适用于佝偻病的早期筛查。

Abstract:

OBJECTIVE: To study the role of serum 25-hydroxyvitamin D in the early diagnosis of vitamin D deficiency rickets. METHODS: Concentrations of serum 25(OH)D, calcium, phosphorus and alkaline phosphatase were measured in normal control (n=73), suspected rickets (n=45) and confirmed rickets groups (n=65). Receiver operating characteristic (ROC) curve was used to evaluate the diagnostic value of serum 25(OH)D for rickets. RESULTS: Serum 25(OH)D levels in the suspected and confirmed rickets groups were 83±30 and 72±31 nmol/L respectively, which was lower than in the normal control group (112±37 nmol/L) (P0.05). Vitamin D deficiency rates in the suspected and confirmed rickets groups were higher than in the control group (P0.05). CONCLUSIONS: Serum 25(OH)D levels in infants with suspected and confirmed rickets are significantly reduced and this may reflect vitamin D deficiency . Therefore, it may be useful to check serum 25(OH)D levels in screening for rickets.