心肌炎患儿淋巴细胞凋亡的改变

Shift of apoptosis in lymphocyte in children with myocarditis

摘要:

目的 了解心肌炎患儿的淋巴细胞凋亡的改变，进一步探讨心肌炎的发病机理。方法 荧光法检测４１ 例心肌炎患儿外周血淋巴细胞凋亡的改变，同时测定Ｔ 淋巴细胞亚群与免疫球蛋白的变化。结果 心肌炎组淋巴细胞凋亡率高于正常组，且Ｔ 淋巴细胞亚群ＣＤ４ ＋ ，ＣＤ４＋／ＣＤ８ ＋ 明显下降，ＣＤ８ ＋ 增高（ Ｐ＜ ０ ．０１） 。结论 淋巴细胞凋亡过度导致淋巴细胞总量失衡，Ｔ淋巴细胞及体液免疫功能均低下，可能是病毒或支原体感染后引起心肌炎的重要原因之一。

Abstract:

Objective To understand the shift of apoptosis in lymphocyte of children with myocarditis, to investigate the pathogenesis of myocarditis.Methods To detect the shift of apoptosis in T-lymphocyte by immunofluorescence among 41 children with myocarditis including infection of virus and mycoplasma, and the alteration of T-lymphocytic subgroup and immunoglobulin at the same time. Results The apoptosis of lymphocytes in myocarditis group was higher than that of normal group, and T-lymphocytic subgroup CD 4 +, CD 4 +/CD 8 + were distinctly descented, CD 8 + was elevated(P<0.01). Conclusions The excessive apoptosis of lymphocytes lead imbalance of the amount. The low functions of T-lymphocyte and humour immunity are one of the important cause of the myocarditis induced by the infection of virus or mycoplasma.